Evidence map›Paper›PMID 34631181›Full record

ArticleCase reports in nephrology2021

Can Antinuclear Antibodies (ANA) be Monoclonal?

Laura Biederman, Anjali A Satoskar, Mohankumar Doraiswamy, Samir Parikh, Brad Rovin, Brian Mussio, Galina Mikhalina, Sergey V Brodsky

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Laura BiedermanDepartment of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Anjali A SatoskarDepartment of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Mohankumar DoraiswamyDepartment of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Samir ParikhDepartment of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Brad RovinDepartment of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Brian MussioHypertension Nephrology Consultants Inc., Columbus, OH, USA.
Galina MikhalinaRochester Regional Health Nephrology, Rochester, NY, USA.
Sergey V BrodskyDepartment of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.ORCID https://orcid.org/0000-0003-4570-5883
The Ohio State University Wexner Medical Center · USHypertension Institute · USNationwide Children's Hospital · USTexas Tech University · USUnity Health System · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNuclear staining by immunofluorescence in a kidney biopsy is often seen in patients with positive antinuclear antibodies (ANA) in the serum. These ANA are usually polyclonal, but herein we report 9 cases with an unusual finding of monoclonal nuclear staining by immunofluorescence on kidney biopsy.

conclusionsWe identified a new unique pattern of nuclear stain by immunofluorescence in kidney biopsies that suggests the presence of monoclonal ANA. Workup for underlying monoclonal gammopathy is warranted in such patients.

Identifiers

PMID34631181
PMCPMC8497151
OpenAlexW3202240438

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.