ArticleIranian journal of basic medical sciences2021
Ameliorative effects of crocin on the inflammation and oxidative stress-induced kidney damages by experimental periodontitis in rat.
Article in Iranian journal of basic medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
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- Use of Nigella sativa silver nanocomposite as an alternative therapy against thioacetamide nephrotoxicity.Genes & nutrition · 2025Article
- Troxerutin alleviates hepatorenal toxicity induced by carbon tetrachloride in male mice.Iranian journal of basic medical sciences · 2025Article
- Article
- Does crocin create new hope for the treatment of oral problems? A focus on periodontitis.Molecular biology reports · 2024Review
- Defense against oxidative stress inFrontiers in veterinary science · 2023Article
- Comparative study of oral versus parenteral crocin in mitigating acrolein-induced lung injury in albino rats.Scientific reports · 2022Article
- Crocin ameliorates MicroRNAs-associated ER stress in type 2 diabetes induced by methylglyoxal.Iranian journal of basic medical sciences · 2022Article
- Biological Effect of Quercetin in Repairing Brain Damage and Cerebral Changes in Rats: Molecular Docking and In Vivo Studies.BioMed research international · 2022Article
- Protective Mechanism of Leucine and Isoleucine against HOxidative medicine and cellular longevity · 2022Article
- Neuroprotective effects of crocin and crocin-loaded niosomes against the paraquat-induced oxidative brain damage in rats.Open life sciences · 2022Article
- Antioxidant Effects of Curcumin Gel in Experimental Induced Diabetes and Periodontitis in Rats.BioMed research international · 2022Article
- Evaluation of the protective effect of coenzyme QInternational journal of immunopathology and pharmacologyArticle
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe present study aimed to investigate the effects of periodontitis on kidneys and the protective role of crocin in periodontitis-induced kidney damage. MATERIALS AND
methodsEthics committee approval was obtained and 30 Wistar rats were randomly divided into 3 groups of 10 rats: Control (C), Periodontitis (P), and Periodontitis + Crocin (P + Cr). After the treatments, rat kidney tissues were incised under anesthesia and blood samples were collected. Biochemical and histopathological analyses were conducted on the samples.
resultsMalondialdehyde (MDA), total oxidant status (TOS), and oxidative stress index (OSI) increased in P group rat kidney tissues; urea, creatinine, Tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin 1β (IL-1β) levels increased in the serum; glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and total antioxidant status (TAS) levels were reduced in rat kidney tissues, and renal histopathology deteriorated. In the P + Cr group, we observed improvements in biochemical and histopathological parameters when compared with the P group.
conclusionPeriodontitis (P) led to deterioration in oxidative stress parameters and histopathology by increasing the oxidants in kidney tissue. P also led to inflammation in the blood of the rats. Periodontitis + Crocin (P + Cr) administration alleviated the effects of P due to powerful antioxidant anti-inflammatory properties. Cr could be employed as a protective agent in P-induced inflammation and oxidative damage.
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