ArticleComputational and structural biotechnology journal2021
A mathematical model of the circadian clock and drug pharmacology to optimize irinotecan administration timing in colorectal cancer.
Article in Computational and structural biotechnology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 46 citations in OpenAlex.
- Circadian rhythm disruption by PARP inhibitors correlates with treatment toxicity in patients with ovarian cancer and is a predictor of side effects.EBioMedicine · 2025Trial
- Time after time - circadian clocks through the lens of oscillator theory.FEBS letters · 2026Review
- Data-driven discovery of digital twins in biomedical research.Briefings in bioinformatics · 2026Review
- Chrono-immunotherapy's current and future optimization strategies: immunotherapy timing in line with the circadian rhythm brings longer survival benefits.Frontiers in immunology · 2026Review
- Personalized chronotherapy in glioblastoma: integrating circadian profiling and PK-PD modelling to optimize temozolomide timing.NPJ precision oncology · 2025Article
- Circadian rhythm in gastrointestinal cancer: clinical applications and future perspectives.Annals of medicine · 2025Review
- Circadian clock model with sequestration repression motif: existence of periodic orbits and entrainment properties.Interface focus · 2025Article
- A combined mathematical and experimental approach reveals the drivers of time-of-day drug sensitivity in human cells.Communications biology · 2025Article
- CirRFKB: A knowledgebase of circadian-related risk factors for cancer pathogenesis and personalized medicine.Computational and structural biotechnology journal · 2025Article
- Circadian Rhythm Disruption in Cancer Survivors: From Oncogenesis to Quality of Life.Cancer medicine · 2024Review
- Chronobiology of Cancers in the Liver and Gut.Cancers · 2024Review
- A comprehensive review of computational cell cycle models in guiding cancer treatment strategies.NPJ systems biology and applications · 2024Review
- Crosstalk between Circadian Rhythm Dysregulation and Tumorigenesis, Tumor Metabolism and Tumor Immune Response.Aging and disease · 2024Review
- Molecular characterization of the circadian clock in patients with Parkinson's disease-CLOCK4PD Study protocol.PloS one · 2024Article
- Artificial Intelligence in Sleep Medicine: The Dawn of a New Era.Nature and science of sleep · 2024Article
- The Circadian Clock as a Potential Biomarker and Therapeutic Target in Gastrointestinal Cancers.Current pharmaceutical design · 2024Review
- CIRCUST: A novel methodology for temporal order reconstruction of molecular rhythms; validation and application towards a daily rhythm gene expression atlas in humans.PLoS computational biology · 2023Article
- An integrative mathematical model for timing treatment toxicity and Zeitgeber impact in colorectal cancer cells.NPJ systems biology and applications · 2023Article
- Modeling the Circadian Control of the Cell Cycle and Its Consequences for Cancer Chronotherapy.Biology · 2023Article
- Hair Follicles as a Critical Model for Monitoring the Circadian Clock.International journal of molecular sciences · 2023Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Scheduling anticancer drug administration over 24 h may critically impact treatment success in a patient-specific manner. Here, we address personalization of treatment timing using a novel mathematical model of irinotecan cellular pharmacokinetics and -dynamics linked to a representation of the core clock and predict treatment toxicity in a colorectal cancer (CRC) cellular model. The mathematical model is fitted to three different scenarios: mouse liver, where the drug metabolism mainly occurs, and two human colorectal cancer cell lines representing an
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.