Evidence map›Paper›PMID 34630868›Full record

ArticleInternational IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering2021

Recruitment of Primary Afferents by Dorsal Root Ganglion Stimulation using the Injectrode.

Ashley N Dalrymple, Jordyn E Ting, Rohit Bose, Stephan Nieuwoudt, Manfred Franke, Kip A Ludwig, Andrew J Shoffstall, Lee E Fisher, Douglas J Weber

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Ashley N DalrympleDepartment of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA.
Jordyn E TingRehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA, USA.
Rohit BoseRehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA, USA.
Stephan NieuwoudtNeuronoff Inc., Cleveland, OH, USA.
Manfred FrankeNeuronoff Inc., Cleveland, OH, USA.
Kip A LudwigNeuronoff Inc., Cleveland, OH, USA.
Andrew J ShoffstallNeuronoff Inc., Cleveland, OH, USA.
Lee E FisherRehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA, USA.
Douglas J WeberDepartment of Mechanical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA.
University of Pittsburgh · USCarnegie Mellon University · USCase Western Reserve University · USCenter for the Neural Basis of Cognition · USUniversity of Wisconsin–Madison · US

Funding

The Injectrode - A Truly Injectable Electrode for Dorsal Root Ganglion Stimulation to Treat PainU18EB029251 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI LUDWIG, KIP A, WEBER, DOUGLAS J · 2019 to 2021
$2.5M
NIBIB NIH HHS U18 EB029251
6 · The paper itself

Abstract

Chronic pain affects millions of people in the United States and pharmacological treatments have been ineffective. Dorsal root ganglion (DRG) stimulation is a neuromodulation method that delivers electrical stimulation to the DRG to relieve pain. DRG electrodes are rigid and cylindrical. The implantation of DRG electrodes requires a technically-challenging surgery that involves steering electrodes laterally towards the DRG. The Injectrode is an injectable conductive polymer that cures in place and is capable of delivering electrical current to stimulate neural tissue. We used the Injectrode to stimulate the L6 and L7 DRG in cats, measuring neural responses evoked in the sciatic, tibial, and common peroneal nerves to measure the thresholds for activating fibers. A cylindrical stainless-steel electrode was used for comparison. Thresholds were 38% higher with the Injectrode versus stainless-steel, likely owing to its larger contact surface area with the DRG. Both Aα and Aβ sensory fibers were activated using DRG stimulation. The Injectrode has the potential to offer a new and simple method for DRG stimulation that can potentially offer more complete coverage of the DRG.

Identifiers

PMID34630868
PMCPMC8502004
OpenAlexW3166429712

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.