Evidence map›Paper›PMID 34630776›Full record

ReviewThe Japanese dental science review2021

Impact of tribocorrosion and titanium particles release on dental implant complications - A narrative review.

Waad Kheder, Sausan Al Kawas, Khaled Khalaf, A R Samsudin

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Japanese dental science review, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 80 citations in OpenAlex.

  1. Assessment of ion release, cytotoxicity, and potential systemic toxicity of titanium dental alloy.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Titanium Dental Implant Corrosion in Peri-Implantitis and Implant Failure.Advances in experimental medicine and biology · 2026
    Review
  7. Review
  8. Article
  9. Article
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  11. Review
  12. Article
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  14. Review
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  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Waad KhederCollege of Dental Medicine, University of Sharjah, P.O. Box 27272, United Arab Emirates.
Sausan Al KawasCollege of Dental Medicine, University of Sharjah, P.O. Box 27272, United Arab Emirates.
Khaled KhalafCollege of Dental Medicine, University of Sharjah, P.O. Box 27272, United Arab Emirates.
A R SamsudinCollege of Dental Medicine, University of Sharjah, P.O. Box 27272, United Arab Emirates.
University of Sharjah · AE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Titanium particles as a product of degradation have been detected in periimplant oral tissues and it has been assumed that implants were the source of these particles. Periimplantitis sites had higher concentrations of particles in comparison to healthy implant sites. Several factors have been identified in the degradation of dental implant surface, such as mechanical wear, contact with chemical agents, and the effects of biofilm adhesion. Titanium particles silently prompt the immune-system activation and generate a pro-inflammatory response in macrophages, T lymphocytes and monocytes. During the activation, inflammatory cytokines are released including, granulocyte-macrophage colony-stimulating factor (GM-CSF), prostaglandin, and TNF-α, IL-1β, IL-6. The nanoparticles depict unique features such as high level of biological reactivity and potentially harmful compared to microparticles since they have a relatively greater surface area to volume ratio. Allergic response to titanium as a cause of implant failure has not been well documented. Evidence demonstrating biological complication due to titanium particles release includes peri-implant tissue inflammation that lead terminally to implant loss. There is a biological probability for a relation between the presence of titanium particles and ions, biological complication, and corrosion, but there is no justifiable evidence for unidirectional series of causative actions.

Indexed as

Implant corrosionImplant degradationImplant wearPeriimplantitisTitanium implantTitanium particles

Identifiers

PMID34630776
PMCPMC8488597
OpenAlexW3202951765

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.