ReviewEvidence-based complementary and alternative medicine : eCAM2021
Association between Obstructive Sleep Apnea and Type 2 Diabetes Mellitus: A Dose-Response Meta-Analysis.
Review in Evidence-based complementary and alternative medicine : eCAM, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association between obstructive sleep apnea syndrome and type1/type2 diabetes mellitus: A systematic review and meta-analysis.Journal of diabetes investigation · 2025Pooled it
- Association between obstructive sleep apnea and multiple adverse clinical outcomes: evidence from an umbrella review.Frontiers in medicine · 2025Pooled it
- The relationship between obstructive sleep apnea and insulin resistance in patients with type 2 diabetes mellitus: a cross-sectional observational study.Journal of thoracic disease · 2026Article
- Chronic intermittent hypoxia affects the expression of IRS - 2/p - Akt/GSK - 3 in the liver of SD rats and its impact on glucose metabolism.Sleep & breathing = Schlaf & Atmung · 2025Article
- Intermittent Hypoxia as a Model of Obstructive Sleep Apnea: Present and Future.Sleep medicine clinics · 2025Review
- Characterization of sleep apnea among a sample of adults from Samoa.Sleep epidemiology · 2024Article
- Sleep and cardiovascular disease.Emerging topics in life sciences · 2023Review
- Redefining Comorbid Insomnia and Sleep Apnea: The Association of Sleep Breathing Impairment and Insomnia with Incident Diabetes.Annals of the American Thoracic Society · 2023Article
- Shorter respiratory event duration is related to prevalence of type 2 diabetes.Frontiers in endocrinology · 2023Article
- The role of ferroptosis in chronic intermittent hypoxia-induced lung injury.BMC pulmonary medicine · 2022Article
- Sleep Apnea and Cardiovascular Risk in Patients with Prediabetes and Type 2 Diabetes.Nutrients · 2022Review
- Identification of Gene Coexpression Modules and Prognostic Genes Associated with Papillary Thyroid Cancer.Journal of oncology · 2022Article
- The critical issue linking lipids and inflammation: Clinical utility of stopping oxidative stress.Frontiers in cardiovascular medicine · 2022Review
- Brazilian Thoracic Association Consensus on Sleep-disordered Breathing.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2022Article
- X-Ray Cephalometric Analysis of the Effects of Angle Class II and III Malocclusion on the Upper Airway Width and Hyoid Position between Parents and Children of Uygur Nationality.Computational and mathematical methods in medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MATERIALS AND
methodsWe screened four databases (PubMed, Embase, Cochran Library, and CNKI) for the observational studies about the OSA and T2DM. Studies were collected from database establishment to October 2020. We performed a traditional subgroup meta-analysis. What is more, linear and spline dose-response models were applied to assess the association between apnea-hypopnea index (AHI), an indicator to evaluate the severity of OSA, and the risk of T2DM. Review Manager, version 5.3, software and Stata 16.0 were used for the analysis.
resultSeven observational studies were included in the research. We excluded a study in the conventional meta-analysis. In the subgroup analysis, mild-dose AHI increased the risk of T2DM (odds ratio = 1.23, 95% confidence interval = 1.06-1.41,
conclusionThrough the dose-response meta-analysis, we found a potential dose-response relationship existed between the severity of OSA and the risk of T2DM. This relationship in our passage should be considered in the prevention of T2DM in the future.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.