ArticleFrontiers in genetics2021
Diversity Scaling of Human Digestive Tract (DT) Microbiomes: The Intra-DT and Inter-individual Patterns.
Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Spatial scaling of metagenomic diversity reveals ecological disruption in the gut microbiome of gout patients.Scientific reports · 2026Article
- Gene and function diversity-area relationships in the inflammatory bowel disease fecal and mucosal microbiome.Frontiers in microbiology · 2025Article
- Host-Population Microbial Diversity Scaling of Chinese Gut Microbiomes in Gout Patients.Evolutionary bioinformatics online · 2022Article
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Authors and funding
6 authors.
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Abstract
The human gut microbiome has been extensively studied, but its diversity scaling (changes or heterogeneities) along the digestive tract (DT) as well as their inter-individual heterogeneities have not been adequately addressed to the best of our knowledge. Here we fill the gap by applying the diversity-area relationship (DAR), a recent extension to the classic species-area relationship (SAR) in biogeography, by reanalyzing a dataset of over 2000 16s-rRNA microbiome samples obtained from 10 DT sites of over 200 individuals. We sketched out the biogeography "maps" for each of the 10 DT sites by cross-individual DAR analysis, and the intra-DT distribution pattern by cross-DT-site DAR analysis. Regarding the inter-individual biogeography, it was found that all DT sites have the invariant (constant) scaling parameter-all sites possessing the same diversity change rate across individuals, but most sites have different
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