Evidence map›Paper›PMID 34630426›Full record

ReviewFrontiers in immunology2021

Host Immune-Metabolic Adaptations Upon Mycobacterial Infections and Associated Co-Morbidities.

Alba Llibre, Martin Dedicoat, Julie G Burel, Caroline Demangel, Matthew K O'Shea, Claudio Mauro

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Meta-analysis reveals a core iron-responsive gene signature in Mycobacterium tuberculosis linking siderophore biosynthesis, virulence, and metabolic adaptation.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Pooled it
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  16. Modulation of the Response toFrontiers in microbiology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Alba LlibreInstitute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.
Martin DedicoatDepartment of Infectious Diseases, Heartlands Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom.
Julie G BurelDivision of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA, United States.
Caroline DemangelImmunobiology of Infection Unit, Institut Pasteur, INSERM U1224, Paris, France.
Matthew K O'SheaDepartment of Infectious Diseases, Heartlands Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom.
Claudio MauroInstitute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.
University of Birmingham · GBHeartlands Hospital · GBInserm · FRLa Jolla Institute for Immunology · USUniversity Hospitals Birmingham NHS Foundation Trust · GB

Funding

Medical Research Council MR/P021220/1Medical Research Council MR/T016736/1
6 · The paper itself

Abstract

Mycobacterial diseases are a major public health challenge. Their causative agents include, in order of impact, members of the

Indexed as

Adaptation, PhysiologicalAnimalsHost-Pathogen InteractionsHumansMacrophagesMycobacteriumMycobacterium Infectionshost-directed therapiesimmunometabolismmacrophagemycobacteriatuberculosis

Identifiers

PMID34630426
PMCPMC8495197
OpenAlexW3202139046

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.