Evidence map›Paper›PMID 34630393›Full record

ArticleFrontiers in immunology2021

Sex Hormones and Aging Modulate Interferon Lambda 1 Production and Signaling by Human Uterine Epithelial Cells and Fibroblasts.

Mickey V Patel, Daniel C Hopkins, Fiona D Barr, Charles R Wira

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Microbiota-dependent IFN-L controls uterine and placental immunity.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
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  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mickey V PatelDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH, United States.
Daniel C HopkinsDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH, United States.
Fiona D BarrDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH, United States.
Charles R WiraDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH, United States.
Dartmouth College · US

Funding

Impact of Aging on Mucosal Immune Protection in the Female ReproductiveR01AG064794 · NIA · DARTMOUTH COLLEGE · PI WIRA, CHARLES ROBERT · 2019 to 2023
$2.8M
Innate Immune Protection Against HIV-1 by Reproductive Tract Epithelial CellsR01AI071761 · NIAID · DARTMOUTH COLLEGE · PI WIRA, CHARLES ROBERT · 2007 to 2014
$2.6M
Menstrual Cycle Control of HIV Infection in the Reproductive TractR01AI102838 · NIAID · DARTMOUTH COLLEGE · PI WIRA, CHARLES ROBERT · 2012 to 2016
$2.2M
Innate Immune Protection Against HIV-1 by Reproductive Tract Epithelial CellsR56AI071761 · NIAID · DARTMOUTH COLLEGE · PI WIRA, CHARLES ROBERT · 2007 to 2007
$167k
NIAID NIH HHS R01 AI071761NIAID NIH HHS R01 AI102838NIAID NIH HHS R56 AI071761NIA NIH HHS R01 AG064794
6 · The paper itself

Abstract

Estradiol (E

Indexed as

Signal TransductionAdultAgedAged, 80 and overAgingCell LineCells, CulturedCytokinesEndometriumEpithelial CellsEstradiolFemaleFibroblastsGonadal Steroid HormonesHumansInterferon LambdaCytokinesEstradiolGonadal Steroid HormonesInterferon Lambdainterferon-lambda, humanInterferonsInterleukinsProgesteroneestradiolinterferon lambda (IFN-λ)interferon-stimulated gene (ISG)progesteroneuterine epithelial celluterine stromal cell

Identifiers

PMID34630393
PMCPMC8497887
OpenAlexW3203358158

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.