Evidence map›Paper›PMID 34630381›Full record

ArticleFrontiers in immunology2021

Crosstalk Between CD11b and Piezo1 Mediates Macrophage Responses to Mechanical Cues.

Hamza Atcha, Vijaykumar S Meli, Chase T Davis, Kyle T Brumm, Sara Anis, Jessica Chin, Kevin Jiang, Medha M Pathak, Wendy F Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.

  1. Pooled it
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  7. Review
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  12. Review
  13. PIEZO1 in Immune Cells: From Force to Function.Results and problems in cell differentiation · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Hamza AtchaDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA, United States.
Vijaykumar S MeliDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA, United States.
Chase T DavisDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA, United States.
Kyle T BrummDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA, United States.
Sara AnisDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA, United States.
Jessica ChinDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA, United States.
Kevin JiangDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA, United States.
Medha M PathakDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA, United States.
Wendy F LiuDepartment of Biomedical Engineering, University of California, Irvine, Irvine, CA, United States.
University of California, Irvine · USEdwards Lifesciences (United States) · US

Funding

Biophysical regulation of macrophage functionR01AI151301 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI LIU, WENDY · 2020 to 2024
$2.9M
Engineering Biomaterials to Exert Molecular Control of Immune Cell FunctionDP2DE023319 · NIDCR · UNIVERSITY OF CALIFORNIA-IRVINE · PI LIU, WENDY · 2012 to 2012
$2.3M
Piezo1 in neural stem cell mechano-regulationR01NS109810 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI PATHAK, MEDHA M · 2018 to 2022
$2.2M
Training Program in Cardiovascular Applied Research and EntrepreneurshipT32HL116270 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI HUGHES, CHRISTOPHER C. W. · 2013 to 2022
$1.6M
Mechanochemical regulation of macrophages by the extracellular matrix during wound healingR21AI128519 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI LIU, WENDY · 2017 to 2018
$405k
NHLBI NIH HHS T32 HL116270NIAID NIH HHS R01 AI151301NIAID NIH HHS R21 AI128519NIDCR NIH HHS DP2 DE023319NINDS NIH HHS R01 NS109810
6 · The paper itself

Abstract

Macrophages are versatile cells of the innate immune system that perform diverse functions by responding to dynamic changes in their microenvironment. While the effects of soluble cues, including cytokines and chemokines, have been widely studied, the effects of physical cues, including mechanical stimuli, in regulating macrophage form and function are less well understood. In this study, we examined the effects of static and cyclic uniaxial stretch on macrophage inflammatory and healing activation. We found that cyclic stretch altered macrophage morphology and responses to IFNγ/LPS and IL4/IL13. Interestingly, we found that both static and cyclic stretch suppressed IFNγ/LPS induced inflammation. In contrast, IL4/IL13 mediated healing responses were suppressed with cyclic but enhanced with static stretch conditions. Mechanistically, both static and cyclic stretch increased expression of the integrin CD11b (α

Indexed as

Mechanotransduction, CellularAnimalsCD11b AntigenCells, CulturedCell SurvivalFemaleIon ChannelsMacrophage ActivationMacrophagesMiceMice, Inbred C57BLMice, TransgenicCD11b AntigenIon ChannelsPiezo1 protein, mouseinflammationintegrinmacrophagepiezo1stretch

Identifiers

PMID34630381
PMCPMC8493066
OpenAlexW3198953402

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.