ArticleFrontiers in endocrinology2021
Prolonged Cryopreservation Negatively Affects Embryo Transfer Outcomes Following the Elective Freeze-All Strategy: A Multicenter Retrospective Study.
Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Optimal timing for frozen-thawed embryo transfer: evidence from a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Impact of prolonged embryo storage on reproductive and neonatal outcomes: a systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2024Pooled it
- Autofluorescence imaging reveals the impact of cryopreservation on T cell metabolism and activation response.Molecular therapy. Advances · 2026Article
- Enhanced exosomes for fertility protection against chemotherapy-induced ovarian damage.NPJ Regenerative medicine · 2026Article
- Does Prolonged Preservation of Blastocysts Affect the Implantation and Live Birth Rate? A Danish Nationwide Register-Based Study.Journal of clinical medicine · 2026Article
- Effect of cryopreservation duration on pregnancy outcomes in embryos: a systematic review and meta-analysis.Human reproduction open · 2026Review
- Autofluorescence imaging reveals the impact of cryopreservation on T cell metabolism and activation response.bioRxiv : the preprint server for biology · 2025Article
- Thyroid autoimmunity is strongly associated with embryo quality in infertile euthyroid women receiving IVF/ICSI, especially patients with TSH values above 2.5 uIU/mL and poor ovarian response.BMC pregnancy and childbirth · 2025Article
- Effectiveness and safety of consecutive single embryo transfer compared to double embryo transfer: results from the UK HFEA registry.Human reproduction (Oxford, England) · 2025Article
- Patient-specific predictors of successful frozen embryo transfer using the freeze-all protocol: a retrospective observational study.Journal of Yeungnam medical science · 2025Article
- Impact of embryo transfer strategies on children health outcomes: a retrospective national cohort study in Taiwan.Frontiers in endocrinology · 2025Article
- Unlocking Success: The Optimal Gonadotrophin Starting Point for Luteal-Phase Stimulation in IVF Patients with Normal Responses.International journal of women's health · 2025Article
- Vitrification preservation of good-quality blastocysts for more than 5 years reduces implantation and live birth rates.Human reproduction (Oxford, England) · 2024Article
- Embryo transfer impact: a comprehensive national cohort analysis comparing maternal and neonatal outcomes across varied embryo stages in fresh and frozen transfers.Frontiers in endocrinology · 2024Article
- Improved pregnancy rate and sex ratio in fresh/frozenJournal of animal science and technology · 2023Article
- Storage duration of vitrified embryos does not affect pregnancy and neonatal outcomes after frozen-thawed embryo transfer.Frontiers in endocrinology · 2023Article
- An Update on Non-invasive Approaches for Genetic Testing of the Preimplantation Embryo.Current genomics · 2022Review
- Preconception Dietary Patterns and Associations With IVF Outcomes: An Ongoing Prospective Cohort Study.Frontiers in nutrition · 2022Article
- Effect of Long-Term Embryo Cryopreservation on Subsequent Frozen Embryo Transfer Outcomes: A Retrospective Cohort Study.Journal of human reproductive sciencesArticle
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: With the development of embryo freezing and warming technology, frozen-thawed embryo transfer (FET) has been widely utilized. However, studies investigating the association between cryopreservation duration and FET outcomes are limited and controversial, and previous studies did not conduct stratification analyses based on demographic or clinical characteristics. Methods: This multicenter retrospective study included 17,826 women who underwent their first FET following the freeze-all strategy during the period from January 2014 to December 2018. Duration of cryopreservation was categorized into five groups: 3-8 weeks, 8-12 weeks, 12-26 weeks, 26-52 weeks, and >52 weeks. Modified Poisson regression and multivariate logistic regression were used to assess the association between cryostorage time of vitrified embryos and transfer outcomes. Moreover, further stratification analyses were performed according to variables with Results: In this large multicenter study, we observed that storage duration was inversely associated with the possibility of pregnancy and live birth ( Conclusion: The results of this large, multicenter, retrospective study suggested that prolonged cryopreservation was inversely associated with the probability of pregnancy and live birth. Therefore, for patients who adopt a freeze-all strategy, early FET might achieve a better outcome.
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