Evidence map›Paper›PMID 34630091›Full record

ArticleFrontiers in pharmacology2021

Kv1.3 Channel Up-Regulation in Peripheral Blood T Lymphocytes of Patients With Multiple Sclerosis.

Ioannis Markakis, Ioannis Charitakis, Christine Beeton, Melpomeni Galani, Elpida Repousi, Stella Aggeloglou, Petros P Sfikakis, Michael W Pennington, K George Chandy, Cornelia Poulopoulou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Ioannis MarkakisNational and Kapodistrian University of Athens, Medical School, Athens, Greece.
Ioannis CharitakisNational and Kapodistrian University of Athens, Medical School, Athens, Greece.
Christine BeetonDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA, United States.
Melpomeni GalaniNational and Kapodistrian University of Athens, Medical School, Athens, Greece.
Elpida RepousiNational and Kapodistrian University of Athens, Medical School, Athens, Greece.
Stella AggeloglouDepartment of Neurology, "St. Panteleimon" General State Hospital, Nikaia, Greece.
Petros P SfikakisNational and Kapodistrian University of Athens, Medical School, Athens, Greece.
Michael W PenningtonAmbiopharm, Inc., North Augusta, SC, United States.
K George ChandyDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA, United States.
Cornelia PoulopoulouNational and Kapodistrian University of Athens, Medical School, Athens, Greece.
National and Kapodistrian University of Athens · GRGeneral Hospital of Nikea · GRBaylor College of Medicine · USUniversity of California, Irvine · US

Funding

K-Channels in Lymphocyte Function and AutoimmunityR01NS048252 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHANDY, GEORGE KANIANTHARA · 2005 to 2012
$2.0M
NINDS NIH HHS R01 NS048252
6 · The paper itself

Abstract

Voltage-gated Kv1.3 potassium channels are key regulators of T lymphocyte activation, proliferation and cytokine production, by providing the necessary membrane hyper-polarization for calcium influx following immune stimulation. It is noteworthy that an accumulating body of

Indexed as

calcium regulationKv1.3multiple sclerosispatch clamppotassium channelsT cells

Identifiers

PMID34630091
PMCPMC8495199
OpenAlexW3204226501

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.