Evidence map›Paper›PMID 34630046›Full record

ArticleFrontiers in neural circuits2021

The Role of Hub Neurons in Modulating Cortical Dynamics.

Eyal Gal, Oren Amsalem, Alon Schindel, Michael London, Felix Schürmann, Henry Markram, Idan Segev

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neural circuits, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Eyal GalThe Edmond & Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.
Oren AmsalemDepartment of Neurobiology, The Hebrew University of Jerusalem, Jerusalem, Israel.
Alon SchindelDepartment of Neurobiology, The Hebrew University of Jerusalem, Jerusalem, Israel.
Michael LondonThe Edmond & Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.
Felix SchürmannBlue Brain Project, École Polytechnique Fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland.
Henry MarkramBlue Brain Project, École Polytechnique Fédérale de Lausanne (EPFL), Campus Biotech, Geneva, Switzerland.
Idan SegevThe Edmond & Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.
Hebrew University of Jerusalem · ILÉcole Polytechnique Fédérale de Lausanne · CH

Funding

A multimodal atlas of human brain cell typesU01MH114812 · NIMH · ALLEN INSTITUTE · PI LEIN, ED · 2017 to 2021
$19.2M
NIMH NIH HHS U01 MH114812
6 · The paper itself

Abstract

Many neurodegenerative diseases are associated with the death of specific neuron types in particular brain regions. What makes the death of specific neuron types particularly harmful for the integrity and dynamics of the respective network is not well understood. To start addressing this question we used the most up-to-date biologically realistic dense neocortical microcircuit (NMC) of the rodent, which has reconstructed a volume of 0.3 mm

Indexed as

NeuronsSynapsesBrainNerve Netcell ablation strategycortical microcircuitryhub neuronsnetwork sciencenetwork synchronicityscale free networksmall world topology

Identifiers

PMID34630046
PMCPMC8500625
OpenAlexW3202457327

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.