Evidence map›Paper›PMID 34630033›Full record

ArticleFrontiers in molecular neuroscience2021

NMDARs Drive the Expression of Neuropsychiatric Disorder Risk Genes Within GABAergic Interneuron Subtypes in the Juvenile Brain.

Vivek Mahadevan, Apratim Mitra, Yajun Zhang, Xiaoqing Yuan, Areg Peltekian, Ramesh Chittajallu, Caroline Esnault, Dragan Maric, Christopher Rhodes, Kenneth A Pelkey and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 17 citations in OpenAlex.

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  15. Developmental deficits of MGE-derived interneurons in theFrontiers in cell and developmental biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Vivek MahadevanSection on Cellular and Synaptic Physiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Bethesda, MD, United States.
Apratim MitraBioinformatics and Scientific Programming Core, NICHD, Bethesda, MD, United States.
Yajun ZhangUnit on Cellular and Molecular Neurodevelopment, NICHD, Bethesda, MD, United States.
Xiaoqing YuanSection on Cellular and Synaptic Physiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Bethesda, MD, United States.
Areg PeltekianSection on Cellular and Synaptic Physiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Bethesda, MD, United States.
Ramesh ChittajalluSection on Cellular and Synaptic Physiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Bethesda, MD, United States.
Caroline EsnaultBioinformatics and Scientific Programming Core, NICHD, Bethesda, MD, United States.
Dragan MaricFlow and Imaging Cytometry Core Facility, National Institute of Neurological Disorders and Stroke (NINDS), Bethesda, MD, United States.
Christopher RhodesUnit on Cellular and Molecular Neurodevelopment, NICHD, Bethesda, MD, United States.
Kenneth A PelkeySection on Cellular and Synaptic Physiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Bethesda, MD, United States.
Ryan DaleBioinformatics and Scientific Programming Core, NICHD, Bethesda, MD, United States.
Timothy J PetrosUnit on Cellular and Molecular Neurodevelopment, NICHD, Bethesda, MD, United States.
Chris J McBainSection on Cellular and Synaptic Physiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Bethesda, MD, United States.
Eunice Kennedy Shriver National Institute of Child Health and Human Development · USNational Institute of Neurological Disorders and Stroke · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Medial ganglionic eminence (MGE)-derived parvalbumin (PV)+, somatostatin (SST)+and Neurogliaform (NGFC)-type cortical and hippocampal interneurons, have distinct molecular, anatomical, and physiological properties. However, the molecular mechanisms regulating their maturation remain poorly understood. Here, via single-cell transcriptomics, we show that the obligate NMDA-type glutamate receptor (NMDAR) subunit gene

Indexed as

GABAergic interneuronsmedial ganglionic eminenceneurodevelopmental disordersNMDAR-hypofunctionRibotag-seqschizophreniascRNAseqtranscriptional regulation

Identifiers

PMID34630033
PMCPMC8500094
OpenAlexW3201003686

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.