ArticleFrontiers in neuroscience2021
Altered Functional Topological Organization in Type-2 Diabetes Mellitus With and Without Microvascular Complications.
Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Cognitive changes in people with diabetes with lower extremity complications compared to people with diabetes without lower extremity complications: a systematic review and meta-analysis.BMC endocrine disorders · 2024Pooled it
- Changes of brain function in patients with type 2 diabetes mellitus measured by different analysis methods: A new coordinate-based meta-analysis of neuroimaging.Frontiers in neurology · 2022Pooled it
- Nitric oxide as a mechanistic link between metabolic dysfunction and cognitive decline in type 2 diabetes.Biochemical Society transactions · 2026Review
- Altered static and dynamic effective connectivity in patients with type 2 diabetes mellitus with and without microvascular complications.European journal of medical research · 2025Article
- Role of Necroptosis and Neuroinflammation in CSVD-Associated Cognitive Decline in db/db Mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Visual Deficits in Type 2 Diabetes Mellitus Without Retinopathy: From Retinal Structure to Higher-Level Visual Functions.Translational vision science & technology · 2025Article
- Altered brain functional network connectivity and topology in type 2 diabetes mellitus.Frontiers in neuroscience · 2025Article
- Characterization of changes in the resting-state intrinsic network in patients with diabetic peripheral neuropathy.Scientific reports · 2024Article
- Network efficiency of functional brain connectomes altered in type 2 diabetes patients with and without mild cognitive impairment.Diabetology & metabolic syndrome · 2024Article
- Graph theoretical analysis and independent component analysis of diabetic optic neuropathy: A resting-state functional magnetic resonance imaging study.CNS neuroscience & therapeutics · 2024Article
- Cognition and motion dysfunction-associated brain functional network disruption in diabetic peripheral neuropathy.Human brain mapping · 2024Article
- Altered functional brain networks in coronary heart disease: independent component analysis and graph theoretical analysis.Brain structure & function · 2024Article
- Aberrant Neurovascular Coupling in Diabetic Retinopathy Using Arterial Spin Labeling (ASL) and Functional Magnetic Resonance Imaging (fMRI) methods.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Association between gene expression and altered resting-state functional networks in type 2 diabetes.Frontiers in aging neuroscience · 2023Article
- Aberrant brain functional networks in type 2 diabetes mellitus: A graph theoretical and support-vector machine approach.Frontiers in human neuroscience · 2022Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microvascular complications can accelerate cognitive impairment in patients with type 2 diabetes mellitus (T2DM) and have a high impact on their quality of life; however, the underlying mechanism is still unclear. The complex network in the human brain is the physiological basis for information processing and cognitive expression. Therefore, this study explored the relationship between the functional network topological properties and cognitive function in T2DM patients with and without microvascular complications (T2DM-C and T2DM-NC, respectively). Sixty-seven T2DM patients and 41 healthy controls (HCs) underwent resting-state functional MRI and neuropsychological assessment. Then, graph theoretical network analysis was performed to explore the global and nodal topological alterations in the functional whole brain networks of T2DM patients. Correlation analyses were performed to investigate the relationship between the altered topological parameters and cognitive/clinical variables. The T2DM-C group exhibited significantly higher local efficiency (Eloc), normalized cluster coefficient (γ), and small-world characteristics (σ) than the HCs. Patients with T2DM at different clinical stages (T2DM-C and T2DM-NC) showed varying degrees of abnormalities in node properties. In addition, compared with T2DM-NC patients, T2DM-C patients showed nodal properties disorders in the occipital visual network, cerebellum and middle temporal gyrus. The Eloc metrics were positively correlated with HbA1c level (
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