ReviewJournal of inflammation research2021
Diagnostic and Prognostic Value of Immune/Inflammation Biomarkers for Venous Thromboembolism: Is It Reliable for Clinical Practice?
Review in Journal of inflammation research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed, 69 citations in OpenAlex.
- Neutrophil-to-lymphocyte ratio is associated with 30-day mortality in acute pulmonary embolism across European Society of Cardiology risk categories.Research and practice in thrombosis and haemostasis · 2026Article
- Systemic Inflammation Response Index Predicts Thrombolytic Therapy Requirement in Intermediate-High Risk Acute Pulmonary Embolism: A Retrospective Study.Journal of clinical medicine · 2026Article
- Systemic immune-inflammation index as a predictor of venous thromboembolism in NSCLC patients treated with ICIs: a retrospective study.BMC pulmonary medicine · 2026Article
- Association of thrombocytopenia with deep vein thrombosis in patients with acute exacerbations of chronic obstructive pulmonary disease: A retrospective study.Experimental and therapeutic medicine · 2026Article
- Machine learning prediction of postoperative pulmonary embolism: a multicenter external validation study highlighting inflammatory response and intraoperative hemodynamics.Frontiers in cardiovascular medicine · 2026Article
- Prognostic role of monocyte-to-high-density lipoprotein ratio in mortality of VTE patients at Ardabil (2023-2024).Caspian journal of internal medicine · 2026Article
- Association between triglyceride glucose- systemic immune inflammation index and deep venous thrombosis in fresh fracture patient: a real-world retrospective study.Frontiers in endocrinology · 2026Article
- Evaluating the Predictive Value of the Endothelial Activation and Stress Index in Determining the Severity and Prognosis of Acute Pulmonary Embolism.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2026Article
- Idiopathic hypereosinophilic syndrome complicated by computed tomography-negative cerebral infarction, strangulated intestinal obstruction, and hepatic portal venous gas: a case report of multi-system involvement.Quantitative imaging in medicine and surgery · 2025Article
- Comment on Mureșan et al. Prognostic Nutritional Index, Controlling Nutritional Status (CONUT) Score, and Inflammatory Biomarkers as Predictors of Deep Vein Thrombosis, Acute Pulmonary Embolism, and Mortality in COVID-19 Patients.Diagnostics (Basel, Switzerland) · 2025Article
- Is There a Role for the Neutrophil-to-Lymphocyte Ratio for Rebleeding and Mortality Risk Prediction in Acute Variceal Bleeding? A Comparative 5-Year Retrospective Study.Diseases (Basel, Switzerland) · 2025Article
- A prediction model for persistent postoperative frailty in older patients undergoing elective orthopedic surgery.Medicine · 2025Article
- Padua Score and D-dimer for Pulmonary Embolism Exclusion in the Elderly.Rambam Maimonides medical journal · 2025Article
- Increased prevalence of cardio-cerebrovascular risk factors during the COVID-19 pandemic lockdown: a large, single center, cross-sectional study.BMC medicine · 2025Article
- Inflammatory Biomarkers as Predictors of Symptomatic Venous Thromboembolism in Hospitalized Patients with AECOPD: A Multicenter Cohort Study.Journal of atherosclerosis and thrombosis · 2025Article
- D-dimers or more? Assessing the role of laboratory factors in predicting and confirming pulmonary embolism in high-risk orthopedic patients.Practical laboratory medicine · 2025Article
- The association between prolonged lymphopenia and in-hospital venous thromboembolism among different respiratory virus infections: a retrospective cohort study.Research and practice in thrombosis and haemostasis · 2025Article
- Association between systemic inflammation markers and blood pressure among children and adolescents: National Health and Nutrition Examination Survey.Pediatric research · 2025Article
- The Prognostic Value of Inflammatory Indices in Acute Pulmonary Embolism.Diagnostics (Basel, Switzerland) · 2025Article
- Development and validation of a nomogram prediction model for perioperative deep vein thrombosis risk in arthroplasty: a retrospective study.Frontiers in medicine · 2025Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolism (PE), has been an important cause of sudden in-hospital death. Studies have shown that the immune/inflammatory response plays an important role in the pathogenesis of vascular disease, with representative markers in the blood including the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte/lymphocyte ratio (MLR), systemic immune/inflammatory index (SII), etc. However, there is a variety of immune/inflammatory indicators. Moreover, most previous studies have been single-center investigations involving one or two indicators, with varying nature of cases, number of cases and study objectives, thereby making it difficult to reach consensus conclusions with good clinical guidelines. This article reviews the clinical value of immunoinflammatory indicators for VTE based on previous studies, including the diagnostic and prognostic capabilities. In conclusion, NLR provides promising predictive capability for the onset and prognosis of VTE and deserves extensive application in clinical practice. PLR also has certain diagnostic and prognostic value, but further studies are warranted to identify its reliability and stability. Monocytes, eosinophils and platelet-related indicators show some clinical association with VTE, although the predictive capabilities are mediocre. SII is of promising potential value for VTE and deserves further investigations. This review will provide new clues and valuable clinical guidance for the diagnosis and therapy of VTE.
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