Evidence map›Paper›PMID 34629640›Full record

ArticleArchivos de bronconeumologia2021

Protective Recommendations for Non-invasive Ventilation During COVID-19 Pandemic: A Bench Evaluation of the Effects of Instrumental Dead Space on Alveolar Ventilation.

Mathieu Delorme, Karl Leroux, Ghilas Boussaid, Marius Lebret, Helene Prigent, Antoine Leotard, Bruno Louis, Frédéric Lofaso

Open access · greenAbstract read
In one paragraph

Article in Archivos de bronconeumologia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Mathieu DelormeUniversité Paris-Saclay, UVSQ, ERPHAN, 78000 Versailles, France.
Karl LerouxASV Santé, 92230 Gennevilliers, France.
Ghilas BoussaidUniversité Paris-Saclay, UVSQ, ERPHAN, 78000 Versailles, France.
Marius LebretInstitut Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ), Québec, QC, Canada.
Helene PrigentService de Physiologie - Explorations Fonctionnelles, Unité des Pathologies du Sommeil, AP-HP, Hôpital Raymond Poincaré, 92380 Garches, France.
Antoine LeotardService de Physiologie - Explorations Fonctionnelles, Unité des Pathologies du Sommeil, AP-HP, Hôpital Raymond Poincaré, 92380 Garches, France.
Bruno LouisINSERM, U955, Université Paris Est Créteil, Faculté de Médecine, CNRS ERL 7000, 94010 Créteil, France.
Frédéric LofasoUniversité Paris-Saclay, UVSQ, ERPHAN, 78000 Versailles, France.
Université de Versailles Saint-Quentin-en-Yvelines · FRUniversité Paris-Saclay · FRCentre National de la Recherche Scientifique · FRInserm · FRInstitut Universitaire de Cardiologie et de Pneumologie de Québec · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWith the current COVID-19 pandemic, concerns have raised regarding the risk for NIV to promote airborne transmission. In case of hospital admission, continuation of therapy in patients undergoing chronic NIV is necessary and several protective circuit configurations have been recommended to reduce the risk of aerosol dissemination. However, all these configurations increase instrumental dead space. We therefore designed this study to evaluate their effects on the tidal volume (VT

methodsA bench consisting of a test lung connected to an adult-sized mannequin head was set up. The model was ventilated through usual domiciliary configuration (single limb circuit with facial vented mask) which was used as reference. Then, five different circuit configurations including non-vented facial mask with viral/bacterial filter, modification of leak position, and change from single to double-limb circuit were evaluated. For each configuration, pressure support (PS) was gradually increased to reach reference P

resultsReference P

conclusionsModifications of NIV configurations in the context of COVID-19 pandemic result in substantial increase of instrumental dead space. Re-evaluation of treatment efficiency and settings is crucial whenever protective measures influencing NIV equipment are considered.

Indexed as

CoronavirusInfectious disease transmissionNon-invasive ventilationRespiratory dead spaceRespiratory therapy

Identifiers

PMID34629640
PMCPMC8046339
OpenAlexW3128859135

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.