Evidence map›Paper›PMID 34629493›Full record

ArticleGeburtshilfe und Frauenheilkunde2021

2020 WHO Classification of Female Genital Tumors.

Anne Kathrin Höhn, Christine E Brambs, Grit Gesine Ruth Hiller, Doris May, Elisa Schmoeckel, Lars-Christian Horn

Open access · hybridAbstract read
In one paragraph

Article in Geburtshilfe und Frauenheilkunde, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 234 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
234citing papers in PubMed, 4 pooled it
28.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

234 citing papers in PubMed, 4 syntheses or guidelines pooled it, 362 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. SEOM-GEICO Clinical Guidelines on cervical cancer (2023).Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Guideline
  5. Trial
  6. Trial
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  8. Differentiating high- and low-grade serous ovarian carcinoma using radiomics: a pilot study.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026
    Observational
  9. [Vulvar intraepithelial neoplasia and vulvar cancer].Dermatologie (Heidelberg, Germany) · 2026
    Review
  10. Article
  11. Article
  12. Article
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  14. Article
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174 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Anne Kathrin HöhnArbeitsgruppe Mamma, Gynäko- & Perinatalpathologie, Institut für Pathologie, Universitätsklinikum Leipzig AöR, Leipzig.
Christine E BrambsFrauenklinik, Kantonsspital, Luzern, Schweiz.
Grit Gesine Ruth HillerArbeitsgruppe Mamma, Gynäko- & Perinatalpathologie, Institut für Pathologie, Universitätsklinikum Leipzig AöR, Leipzig.
Doris MayPathologisches Institut der Ludwig-Maximilians-Universität München, München.
Elisa SchmoeckelPathologisches Institut der Ludwig-Maximilians-Universität München, München.
Lars-Christian HornArbeitsgruppe Mamma, Gynäko- & Perinatalpathologie, Institut für Pathologie, Universitätsklinikum Leipzig AöR, Leipzig.
University Hospital Leipzig · DELudwig-Maximilians-Universität München · DELuzerner Kantonsspital · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The 2020 WHO classification is focused on the distinction between HPV-associated and HPV-independent squamous cell carcinoma of the lower female genital organs. Differentiating according to HPV association does not replace the process of grading; however, the WHO classification does not recommend any specific grading system. VIN are also differentiated according to whether they are HPV(p16)-associated. HPV-independent adenocarcinoma (AC) of the cervix uteri has an unfavorable prognosis. Immunohistochemical p16 expression is considered to be a surrogate marker for HPV association. HPV-associated AC of the cervix uteri is determined using the prognostically relevant Silva pattern.

Indexed as

HPVp16 immunohistochemistrySilva pattern

Identifiers

PMID34629493
PMCPMC8494521
OpenAlexW3204903974

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.