Evidence map›Paper›PMID 34629476›Full record

ArticleBiometrika2021

Estimating time-varying causal excursion effect in mobile health with binary outcomes.

Tianchen Qian, Hyesun Yoo, Predrag Klasnja, Daniel Almirall, Susan A Murphy

Open access · greenAbstract read
In one paragraph

Article in Biometrika, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 53 citations in OpenAlex.

  1. Trial
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  3. Self-relevant appeals to engage in self-monitoring of alcohol use: A microrandomized trial.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2023
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  7. Review
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  10. Replicable Bandits for Digital Health Interventions.Statistical science : a review journal of the Institute of Mathematical Statistics · 2025
    Article
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  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Tianchen QianDepartment of Statistics, University of California, Irvine, Donald Bren Hall, Irvine, California 92697, U.S.A.
Hyesun YooDepartment of Statistics, University of Michigan, 323 West Hall, 1085 South University, Ann Arbor, Michigan 48109, U.S.A.
Predrag KlasnjaSchool of Information, University of Michigan, 4364 North Quad, 105 South State Street, Ann Arbor, Michigan 48109, U.S.A.
Daniel AlmirallDepartment of Statistics, University of Michigan, 323 West Hall, 1085 South University, Ann Arbor, Michigan 48109, U.S.A.
Susan A MurphyDepartment of Statistics, Harvard University, 1 Oxford Street, Cambridge, Massachusetts 02138, U.S.A.
University of Michigan–Ann Arbor · USHarvard University · USSouth University · USUniversity of California, Irvine · US

Funding

Pilot, Mentoring, and Professional Development CoreP50DA039838 · NIDA · PENNSYLVANIA STATE UNIVERSITY, THE · PI COLLINS, LINDA M, LANZA, STEPHANIE T · 2015 to 2019
$13.9M
TRAINING U54EB020404 · NIBIB · UNIVERSITY OF MEMPHIS · PI KUMAR, SANTOSH · 2014 to 2018
$11.3M
TR&D3 - Rapid Translation of AI-powered Temporally Precise mHealth Interventions via Efficient and Embeddable Trustworthy Biomarker ImplementationsP41EB028242 · NIBIB · UNIVERSITY OF MEMPHIS · PI VIVEK SHETTY · 2020 to 2026
$9.5M
Novel Methods for Intensive Longitudinal Data in SMART Studies of Drug Abuse and HIVR01DA039901 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALMIRALL, DANIEL, NAHUM-SHANI, INBAL BILLIE · 2015 to 2024
$5.4M
Heart Steps: Adaptive mHealth intervention for physical-activity maintenanceR01HL125440 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Predrag Klasnja · 2015 to 2026
$3.8M
Novel use of mHealth data to identify states of vulnerability and receptivity to JITAIs SupplementU01CA229437 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NAHUM-SHANI, INBAL BILLIE, WETTER, DAVID W · 2018 to 2022
$2.8M
Data-Based Methods for Just-In-Time Adaptive Interventions in Alcohol UseR01AA023187 · NIAAA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MURPHY, SUSAN A · 2015 to 2019
$2.6M
NCI NIH HHS U01 CA229437NHLBI NIH HHS R01 HL125440NIAAA NIH HHS R01 AA023187NIBIB NIH HHS P41 EB028242NIBIB NIH HHS U54 EB020404NIDA NIH HHS P50 DA039838NIDA NIH HHS R01 DA039901
6 · The paper itself

Abstract

Advances in wearables and digital technology now make it possible to deliver behavioral mobile health interventions to individuals in their everyday life. The micro-randomized trial is increasingly used to provide data to inform the construction of these interventions. In a micro-randomized trial, each individual is repeatedly randomized among multiple intervention options, often hundreds or even thousands of times, over the course of the trial. This work is motivated by multiple micro-randomized trials that have been conducted or are currently in the field, in which the primary outcome is a longitudinal binary outcome. The primary aim of such micro-randomized trials is to examine whether a particular time-varying intervention has an effect on the longitudinal binary outcome, often marginally over all but a small subset of the individual's data. We propose the definition of causal excursion effect that can be used in such primary aim analysis for micro-randomized trials with binary outcomes. Under rather restrictive assumptions one can, based on existing literature, derive a semiparametric, locally efficient estimator of the causal effect. Starting from this estimator, we develop an estimator that can be used as the basis of a primary aim analysis under more plausible assumptions. Simulation studies are conducted to compare the estimators. We illustrate the developed methods using data from the micro-randomized trial, BariFit. In BariFit, the goal is to support weight maintenance for individuals who received bariatric surgery.

Indexed as

Binary outcomeCausal excursion effectCausal inferenceLongitudinal dataMicro-randomized trialsMobile healthRelative riskSemiparametric efficiency theory

Identifiers

PMID34629476
PMCPMC8494142
OpenAlexW3083206772

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.