Evidence map›Paper›PMID 34629011›Full record

SynthesisRenal failure2021

Risk factors for mortality in hemodialysis patients with COVID-19: a systematic review and meta-analysis.

Fengping Wang, Guangyu Ao, Yushu Wang, Fuqiang Liu, Mulong Bao, Ming Gao, Shulu Zhou, Xin Qi

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Renal failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fengping WangDepartment of Nephrology, Chengdu Second People's Hospital, Chengdu, PR China.
Guangyu AoDepartment of Nephrology, Chengdu First People's Hospital, Chengdu, PR China.
Yushu WangDepartment of Cardiology, Chengdu First People's Hospital, Chengdu, PR China.
Fuqiang LiuDepartment of Cardiology, Chengdu First People's Hospital, Chengdu, PR China.
Mulong BaoDepartment of Intensive Care Unit, Chengdu First People's Hospital, Chengdu, PR China.
Ming GaoDepartment of Cardiology, Chengdu First People's Hospital, Chengdu, PR China.
Shulu ZhouDepartment of Nephrology, Chengdu First People's Hospital, Chengdu, PR China.
Xin QiDepartment of Neurology, the Affiliated Hospital of Southwest Jiaotong University & the Third People's Hospital of Chengdu, Chengdu, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNew evidence from studies on risk factors for mortality in hemodialysis (HD) patients with COVID-19 became available. We aimed to review the clinical risk factors for fatal outcomes in these patients.

methodsWe performed meta-analysis using the PubMed, EMBASE, and Cochrane databases. A fixed- or random-effects model was used for calculating heterogeneity. We used contour-enhanced funnel plot and Egger's tests to assess potential publication bias.

resultsTwenty-one studies were included. The proportion of males was lower in the survivor group than in the non-survivor group (OR = 0.75, 95% CI [0.61, 0.94]). The proportion of respiratory diseases was significantly lower in the survivor group than in the non-survivor group (OR = 0.42, 95% CI [0.29, 0.60]). The proportion of patients with fever, cough, and dyspnea was significantly lower in the survivor group (fever: OR = 0.53, 95% CI [0.31, 0.92]; cough: OR = 0.50, 95% CI [0.38, 0.65]; dyspnea: OR = 0.25, 95% CI [0.14, 0.47]) than in the non-survivor group. Compared with the non-survivor group, the survivor group had higher albumin and platelet levels and lower leucocyte counts.

conclusionsMale patients might have a higher risk of developing severe COVID-19. Comorbidities, such as respiratory diseases could also greatly influence the clinical prognosis of COVID-19. Clinical features, such as fever, dyspnea, cough, and abnormal platelet, leucocyte, and albumin levels, could imply eventual death. Our findings will help clinicians identify markers for the detection of high mortality risk in HD patients at an early stage of COVID-19.

Indexed as

ComorbidityCOVID-19HumansKidney Failure, ChronicRisk FactorsCOVID-19hemodialysismortalityrisk factor

Identifiers

PMID34629011
PMCPMC8510603

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.