ArticleHypertension (Dallas, Tex. : 1979)2021
IL (Interleukin)-17A Acts in the Brain to Drive Neuroinflammation, Sympathetic Activation, and Hypertension.
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Article in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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0cells of the map it votes in
22citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
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Who cites it
22 citing papers in PubMed, 28 citations in OpenAlex.
- Mechanistic insights into the neuroprotective effects of yangyin formula on cerebral ischemia-reperfusion injury via the IL-17A/MAPK/NF-κB signaling pathway.Journal of molecular histology · 2026Article
- Central Sympathetic Nerve Activation-Mediated Hypertension: Target Mechanisms and Multimodal Interventions-From Basic Research to Clinical Translation.International journal of molecular sciences · 2026Review
- Potential association between IL-17A inhibition and blood pressure reduction in patients with axial spondyloarthritis.Frontiers in immunology · 2026Article
- Development of a High-throughput Morphological Assay for Evaluating Mesenchymal Stromal Cell-derived Extracellular Vesicle Modulation of Brain Pericyte Secretory Phenotype.Stem cell reviews and reports · 2025Article
- Renal denervation alleviates neuroinflammation by suppressing the microglial Ifi27l2a/cGAS-STING signaling axis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Article
- Diet-incorporated saracatinib, a Src tyrosine kinase inhibitor, counteracts diisopropylfluorophosphate (DFP)-induced chronic neurotoxicity in the rat model.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025Article
- Adaptive Immune Dyshomeostasis as a Mediator of Vascular Cognitive Decline: Unraveling Neurovascular Crosstalk.Aging and disease · 2025Review
- IL-17A Induces Circadian Disruptions Through the Epigenetic Repression of BMAL1 in Mice With Alzheimer's Disease.Journal of cellular and molecular medicine · 2025Article
- RORγt Mediates Angiotensin II-Induced Pressor Responses, Microglia Activation, and Neuroinflammation by Disrupting the Blood-Brain Barrier in Rats.Journal of the American Heart Association · 2025Article
- Resistant Hypertension: A Brief Review of Pathophysiology.Journal of general internal medicine · 2025Review
- The immune-microbiome axis in salt-sensitive hypertension: a focus on renal and neural mechanisms.Frontiers in physiology · 2025Review
- Review of mechanisms and frontier applications in IL-17A-induced hypertension.Open medicine (Warsaw, Poland) · 2025Review
- Elevated risk for psychiatric outcomes in pediatric patients with Multisystem Inflammatory Syndrome (MIS-C): A review of neuroinflammatory and psychosocial stressors.Brain, behavior, & immunity - health · 2024Review
- Butyrate attenuates sympathetic activation in rats with chronic heart failure by inhibiting microglial inflammation in the paraventricular nucleus.Acta biochimica et biophysica Sinica · 2024Article
- Immune and inflammatory mechanisms in hypertension.Nature reviews. Cardiology · 2024Review
- Interleukin 17A Contributes to Blood-Brain Barrier Disruption of Hypothalamic Paraventricular Nucleus in Rats With Myocardial Infarction.Journal of the American Heart Association · 2024Article
- Immune cells and hypertension.Immunologic research · 2024Review
- Exogenous IL-17A Alleviates Social Behavior Deficits and Increases Neurogenesis in a Murine Model of Autism Spectrum Disorders.International journal of molecular sciences · 2023Article
- Obstructive Sleep Apnea-Induced Hypertension Is Associated With Increased Gut and Neuroinflammation.Journal of the American Heart Association · 2023Article
- Gut Microbiome and Neuroinflammation in Hypertension.Circulation research · 2022Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Yiling Cao *Department of Internal Medicine (Y.C., Y.Y., S.-G.W.), University of Iowa Carver College of Medicine.
Yang Yu *Department of Internal Medicine (Y.C., Y.Y., S.-G.W.), University of Iowa Carver College of Medicine.
Baojian Xue *Psychological and Brain Sciences (B.X., T.G.B., A.K.J.), University of Iowa Carver College of Medicine.ORCID 0000-0002-6326-0075
Ye WangDepartment of Cardiology, the First Affiliated Hospital of Shandong First Medical University, China (Y.W.).
Xiaolei ChenDepartment of Nephrology, West China Hospital, Sichuan University, Chengdu, China (X.C.).
Terry G BeltzPsychological and Brain Sciences (B.X., T.G.B., A.K.J.), University of Iowa Carver College of Medicine.
Alan Kim JohnsonPsychological and Brain Sciences (B.X., T.G.B., A.K.J.), University of Iowa Carver College of Medicine.
Shun-Guang WeiDepartment of Internal Medicine (Y.C., Y.Y., S.-G.W.), University of Iowa Carver College of Medicine.ORCID 0000-0003-4404-4059
Fujian Medical University · CNHologic (Germany) · DEYo San University · USSichuan University · CNUniversity of Iowa · US
Funding
Novel Role of Interleukin-17 in Sympathetic Activation in Heart FailureR01HL155091 · NHLBI · UNIVERSITY OF IOWA · PI WEI, SHUNGUANG · 2021 to 2025
$2.9MMechanisms of hypertensive response sensitization and perinatal programming of hypertensionR01HL139575 · NHLBI · UNIVERSITY OF IOWA · PI JOHNSON, ALAN KIM, XUE, BAOJIAN · 2018 to 2021
$2.3MTargeting TACE, a novel approach to the treatment of sympathetic excitation in heart failure.R01HL139521 · NHLBI · UNIVERSITY OF IOWA · PI WEI, SHUNGUANG · 2018 to 2022
$1.9MNHLBI NIH HHS R01 HL139521NHLBI NIH HHS R01 HL139575NHLBI NIH HHS R01 HL155091
Abstract
[Figure: see text].
Indexed as
AnimalsBlood-Brain BarrierBrainHypertensionInflammation MediatorsInterleukin-17MaleNeuroinflammatory DiseasesParaventricular Hypothalamic NucleusRatsRats, Sprague-DawleyReceptors, Interleukin-17Sympathetic Nervous SystemTranscriptional ActivationIL17A protein, humanInflammation MediatorsInterleukin-17Receptors, Interleukin-17angiotensin IIautonomic nervous systemblood pressurecytokineshemodynamicsparaventricular hypothalamic nucleus
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.