ArticleVeterinary medicine and science2022
Stereological and molecular studies on the effects of Ferula persica extract on wound healing in rats.
Article in Veterinary medicine and science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 20 citations in OpenAlex.
- A bioactive and biodegradable 3D scaffold derived from dermal matrix and enriched with platelet-rich plasma accelerates wound healing in diabetic rats.Histochemistry and cell biology · 2025Article
- Enhanced skin regeneration in diabetic wounds using collagen-hyaluronic acid scaffold incorporated with epigallocatechin gallate: a multifactorial healing approach.Histochemistry and cell biology · 2025Article
- Investigation of the protective effects of ethanolic extract of ferula orientalis on lung tissue in sepsis model rat.Journal of molecular histology · 2025Article
- The impact of Allgower-Donati suture pattern and postoperative sweet foods on wound suture breakage in experimental rats.Heliyon · 2023Article
- Stereological and molecular studies on the effects of Ferula persica extract on wound healing in rats.Veterinary medicine and science · 2022Article
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5 authors at 3 institutions in 2 countries.
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Abstract
backgroundFerula persica is one of the most important traditional medicinal plants that is used to treat various diseases such as diabetes, backache and rheumatism. The aim of the present study was to evaluate the anti-inflammatory and wound healing potential of F. persica using stereological and molecular methods in experimental models.
methodsIn the present study, two wound models (circular excision and linear incision) were used. Male Wistar rats were divided into four groups (n = 16), including control, vehicle treated, treated with F. persica extract ointment (5% w/w) and treated with the reference drug (Madecassol). All the animals were treated topically once a day. The circular and linear wounds were treated for 9 and 17 days, respectively. At the end of the study, samples from wounds area were harvested for histology, stereology, immunohistochemistry and molecular assessments to determine the in vivo healing potential and anti-inflammatory activity.
resultsWe observed significant recovery in macroscopic evaluation of wound healing in the F. persica extract treated group compared with the control and vehicle treated groups (p < 0.05). Histological and stereological assessments showed complete repair of the epidermal layer, increasing fibroblast cells and collagen density, decreasing inflammatory cells and a remarkable degree of neovascularization by determining length density of blood vessels in the extract group, which were significant as compared to the control and vehicle treated groups (p < 0.05). Expressions of TNF-α and TGF-β were found to be decreased and increased (p > 0.05, p < 0.05, respectively), in the extract treated group as compared to the control and vehicle treated groups. Also, greater COX-2 expression could be detected in the control and vehicle treated groups, which was significantly attenuated in the extract group.
conclusionOur results confirm that the F. persica extract is a valuable source of antioxidant and anti-inflammatory activity and can allow damaged tissue in wounds to recover markedly.
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