ArticleEuropean archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry2021
Evaluation of salivary thiobarbituric acid reactive substances, total protein, and pH in children with various degrees of early childhood caries: a case-control study.
Article in European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.
- Iranian early childhood dental caries: a comprehensive systematic review and meta-analysis of prevalence and associated risk factors.Evidence-based dentistry · 2025Pooled it
- Comparative analysis of the dental plaque metabolome in tooth stain and caries within primary dentition.BMC oral health · 2026Article
- Modulation of dental caries-associated oxidative stress by different restorative materials: A salivary malondialdehyde-basedJournal of conservative dentistry and endodontics · 2026Article
- Evidence-Based Practice for the Use of pH Indicator Paper Strip in Oral Medicine: A Literature Review.Cureus · 2024Review
- Dental Caries and Salivary Oxidative Stress: Global Scientific Research Landscape.Antioxidants (Basel, Switzerland) · 2023Review
- Comparison of oral cavity protein abundance among caries-free and caries-affected individuals-a systematic review and meta-analysis.Frontiers in oral health · 2023Review
- Are Dental Caries Associated with Oxidative Stress in Saliva in Children and Adolescents? A Systematic Review.Metabolites · 2022Review
- Exogenous Pyrroloquinoline Quinone Application Enhances Low-Phosphorus Adaptation in Rice by Modulating Redox Homeostasis Under Variable Light.Physiologia plantarumArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAccording to new studies, oxidative stress may play an important role in the beginning and progression of oral diseases. The aim of this study was the evaluation of thiobarbituric acid reactive substances (TBARS) as an indicator of lipid peroxidation, total protein, and pH of saliva in children with various degrees of early childhood caries in comparison with caries-free children.
methodsThis case-control study was carried out on 90 children 3-5 years old in three equal groups, including caries-free children (CF), early childhood caries (ECC), and severe early childhood caries (S-ECC) who were age- and sex matched. Saliva pH was measured using a paper pH meter and TBARS and total protein were measured by spectrophotometer methods and data were statistically analysed.
resultsTBARS and total protein levels in ECC and S-ECC groups were significantly higher than the CF group (p < 0.001), but pH was not significantly different between groups. There were no significant differences between ECC and S-ECC groups in any of the studied indicators.
conclusionConsidering the limitations of the present study, the results showing the higher salivary TBARS levels in the S-ECC and ECC groups compared to caries-free children, lead to the conclusion that oxidative stress could be considered as a risk factor for early childhood caries.
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