Evidence map›Paper›PMID 34628606›Full record

ArticleDiabetes therapy : research, treatment and education of diabetes and related disorders2021

Relationship Between Bedside Ketone Levels and Time to Resolution of Diabetic Ketoacidosis: A Retrospective Cohort Study.

Yoshihiko Yuyama, Tomoyuki Kawamura, Naoko Nishikawa-Nakamura, Yuko Hotta, Kayako Hashimura, Tomomi Hashimoto, Masakazu Hirose, Takashi Higashide, Takashi Hamazaki

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In one paragraph

Article in Diabetes therapy : research, treatment and education of diabetes and related disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Blood Urea Nitrogen to Serum Albumin Ratio as A New Prognostic Indicator in Critically Ill Patients with Diabetic Ketoacidosis: A Retrospective Cohort Study.Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yoshihiko YuyamaDepartment of Pediatrics, Osaka City University Graduate School of Medicine, Asahi-cho 1-4-3, Abeno-ku, Osaka City, Osaka, 545-8585, Japan.
Tomoyuki KawamuraDepartment of Pediatrics, Osaka City University Graduate School of Medicine, Asahi-cho 1-4-3, Abeno-ku, Osaka City, Osaka, 545-8585, Japan. kawam@med.osaka-cu.ac.jp.
Naoko Nishikawa-NakamuraDepartment of Pediatrics, Osaka City University Graduate School of Medicine, Asahi-cho 1-4-3, Abeno-ku, Osaka City, Osaka, 545-8585, Japan.
Yuko HottaDepartment of Pediatrics, Osaka City University Graduate School of Medicine, Asahi-cho 1-4-3, Abeno-ku, Osaka City, Osaka, 545-8585, Japan.
Kayako HashimuraDepartment of Pediatrics, Osaka City University Graduate School of Medicine, Asahi-cho 1-4-3, Abeno-ku, Osaka City, Osaka, 545-8585, Japan.
Tomomi HashimotoDepartment of Pediatrics, Osaka City University Graduate School of Medicine, Asahi-cho 1-4-3, Abeno-ku, Osaka City, Osaka, 545-8585, Japan.
Masakazu HiroseDepartment of Pediatrics, Osaka City University Graduate School of Medicine, Asahi-cho 1-4-3, Abeno-ku, Osaka City, Osaka, 545-8585, Japan.
Takashi HigashideDepartment of Pediatrics, Osaka City University Graduate School of Medicine, Asahi-cho 1-4-3, Abeno-ku, Osaka City, Osaka, 545-8585, Japan.
Takashi HamazakiDepartment of Pediatrics, Osaka City University Graduate School of Medicine, Asahi-cho 1-4-3, Abeno-ku, Osaka City, Osaka, 545-8585, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThere is no information on the factors that influence the time required to induce resolution of diabetic ketoacidosis (DKA). New methods are currently available for bedside measurement of serum 3-hydroxybutyrate (3HB). The aim of this study was to determine the relationship between serum 3HB and the time to DKA resolution.

methodsWe reviewed the medical records of patients with type 1 diabetes (T1D) and a history of DKA who were admitted to the Department of Pediatrics, Osaka City University Hospital, between November 2008 and October 2018. DKA resolution was defined as 3HB below 1.0 mmol/L as measured by a bedside ketone meter.

resultsData of 52 T1D-DKA episodes were analyzed (median age, 8.0 years; 20 male patients; 32 female patients; new T1D diagnosis, n = 13; established diagnosis, n = 39). In all cases, correction of serum 3HB was an important aspect of T1D management. The median time to DKA resolution (defined as the time from the start of insulin infusion until the fall of 3HB level to below 1.0 mmol/L) was 11 and 10 h in new and established T1D cases, respectively. 3HB on admission and the required insulin infusion dose per body weight, but not blood pH level on admission, correlated with time to DKA resolution. There was no relationship between blood pH level and 3HB on admission.

conclusionsOur results showed that DKA resolution could be achieved within 10-11 h when DKA treatment is guided by bedside 3HB monitoring without any severe complications. Blood 3HB level is a potentially suitable marker for the severity and resolution of DKA.

Indexed as

Bedside ketone body monitoringDiabetic ketoacidosisInsulin doseTime to ketoacidosis resolutionType 1 diabetes

Identifiers

PMID34628606
PMCPMC8586106

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.