Evidence map›Paper›PMID 34628494›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2022

Precise Topology of Adjacent Domain-General and Sensory-Biased Regions in the Human Brain.

Moataz Assem, Sneha Shashidhara, Matthew F Glasser, John Duncan

Abstract read
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. A Cortical Surface-Based Meta-Analysis of Human Reasoning.Cerebral cortex (New York, N.Y. : 1991) · 2021
    Pooled it
  4. Article
  5. Article
  6. Article
  7. Article
  8. Combined Auditory, Tactile, and Visual FMRI Reveals Sensory-Biased and Supramodal Working Memory Regions in the Human Frontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. The Dimensionality of Neural Coding for Cognitive Control Is Gradually Transformed within the Lateral Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  15. Article
  16. Article
  17. Task and stimulus coding in the multiple-demand network.Cerebral cortex (New York, N.Y. : 1991) · 2024
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Moataz AssemMRC Cognition and Brain Sciences Unit, School of Clinical Medicine, University of Cambridge, Cambridge CB2 7EF, UK.
Sneha ShashidharaMRC Cognition and Brain Sciences Unit, School of Clinical Medicine, University of Cambridge, Cambridge CB2 7EF, UK.
Matthew F GlasserDepartment of Neuroscience, Washington University in St. Louis, Saint Louis, MO 63110, USA.
John DuncanMRC Cognition and Brain Sciences Unit, School of Clinical Medicine, University of Cambridge, Cambridge CB2 7EF, UK.

Funding

RECONSTRUCTIONS AND REPRESENTATIONS OF CEREBRAL CORTEXR01MH060974 · NIMH · WASHINGTON UNIVERSITY · PI VAN ESSEN, DAVID C · 1999 to 2024
$12.7M
Medical Research Council MC_UU_00005/6Medical Research Council UAG/045.G101400NIMH NIH HHS R01 MH060974
6 · The paper itself

Abstract

Recent functional MRI studies identified sensory-biased regions across much of the association cortices and cerebellum. However, their anatomical relationship to multiple-demand (MD) regions, characterized as domain-general due to their coactivation during multiple cognitive demands, remains unclear. For a better anatomical delineation, we used multimodal MRI techniques of the Human Connectome Project to scan subjects performing visual and auditory versions of a working memory (WM) task. The contrast between hard and easy WM showed strong domain generality, with essentially identical patterns of cortical, subcortical, and cerebellar MD activity for visual and auditory materials. In contrast, modality preferences were shown by contrasting easy WM with baseline; most MD regions showed visual preference while immediately adjacent to cortical MD regions, there were interleaved regions of both visual and auditory preference. The results may exemplify a general motif whereby domain-specific regions feed information into and out of an adjacent, integrative MD core.

Indexed as

ConnectomeVisual PerceptionBrainBrain MappingHumansMagnetic Resonance ImagingMemory, Short-Termauditory working memorydomain-generalmultiple-demandsensory-biasedvisual working memory

Identifiers

PMID34628494
PMCPMC9201597

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.