ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2022
Low Serum Klotho Associated With All-cause Mortality Among a Nationally Representative Sample of American Adults.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Effects of acute, subacute, and chronic exercise on plasma s-Klotho levels: a systematic review and meta-analysis.Journal of physiology and biochemistry · 2026Pooled it
- Physical exercise and circulating α-Klotho in humans: a systematic review and meta-analysis with emphasis on older adults.Frontiers in sports and active living · 2026Pooled it
- A Western Diet High in Phosphate Primes the Development of the CKD-Mineral Bone Disorder in an Alport Syndrome Model.Kidney360 · 2026Article
- Emerging treatments and current strategies for mineral, vascular, and bone disorders in chronic kidney disease.World journal of nephrology · 2026Review
- Antiaging Properties of the Klotho Protein.Cells · 2026Review
- Fibroblast Growth Factor 23 as a Prognostic Biomarker in Post-Myocardial Infarction Outcomes: Influence of Renal Function and Its Modulation by Klotho.Journal of the American Heart Association · 2026Article
- Association between serum alpha Klotho levels and the likelihood of abdominal aortic calcification.Scientific reports · 2026Article
- Reduced Circulating α-Klotho Levels Are Associated With Elevated Mortality and Arterial Calcifications of Aorta and Iliac Arteries.Journal of the American Heart Association · 2025Article
- Serum klotho levels modify the positive relationship of depression and all-cause mortality risk.Scientific reports · 2025Article
- Klotho: A multifaceted protector in sepsis-induced organ damage and a potential therapeutic target.World journal of critical care medicine · 2025Review
- Observational
- Associations between klotho levels and mortality risk among middle-aged and older adults taking prescription opioids.Preventive medicine reports · 2025Article
- Association between serum α-klotho levels and the incidence of diabetic kidney disease and mortality in type 2 diabetes: evidence from a Chinese cohort and the NHANES database.Diabetology & metabolic syndrome · 2025Article
- A cohort study on the correlation between serum Klotho levels and all-cause mortality in American diabetic populations.Diabetology & metabolic syndrome · 2025Article
- Article
- Interaction Effect of Estimated Pulse Wave Velocity and Serum Klotho Level on Chronic Kidney Disease.Aging medicine (Milton (N.S.W)) · 2025Article
- Metabolically healthy across body mass index categories in relation to serum Klotho levels: a population-based study.Frontiers in endocrinology · 2025Article
- sαKlotho protein is a useful biomarker and a promising cardioprotective agent in acute heart failure.Archives of medical science : AMS · 2025Article
- Correlation of the weight-adjusted waist circumference index with Klotho in the United States: differences by sex.Scientific reports · 2024Article
- The relationship between serum α-Klotho with all-cause and cause-specific mortality.British journal of clinical pharmacology · 2024Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
α-Klotho (klotho) is a protein involved in suppressing oxidative stress and inflammation. In animal models, it is reported to underlie numerous aging phenotypes and longevity. Among a nationally representative sample of adults aged 40-79 years in the United States, we investigated whether circulating concentrations of klotho is a marker of mortality risk. Serum klotho was measured by ELISA on 10 069 individuals enrolled in the National Health and Nutrition Examination Survey between 2007 and 2014. Mortality follow-up data based on the National Death Index were available through December 31, 2015. After a mean follow-up of 58 months (range: 1-108), 616 incident deaths occurred. Using survey-weighted Cox regression models adjusted for age, sex, and survey cycle, low serum klotho concentration (<666 pg/mL) was associated with a 31% higher risk of death (compared to klotho concentration > 985 pg/mL, hazard ratio [HR]: 1.31, 95% confidence interval [CI]: 1.00, 1.71, p = .05). Associations were consistent for mortality caused by heart disease or cancer. Associations of klotho with all-cause mortality did not appear to differ by most participant characteristics. However, we observed effect modification by physical activity, such that low levels of serum klotho were more strongly associated with mortality among individuals who did not meet recommendation-based physical activity guidelines. Our findings suggest that, among the general population of American adults, circulating levels of klotho may serve as a marker of mortality risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.