ArticleProgress in neurobiology2022
Latent brain state dynamics and cognitive flexibility in older adults.
Article in Progress in neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Bayesian dynamical system analysis of the effects of methylphenidate in children with attention-deficit/hyperactivity disorder: a randomized trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Trial
- Inter-individual differences in baseline dynamic functional connectivity are linked to cognitive aftereffects of tDCS.Scientific reports · 2022Trial
- Hierarchical neural variability reveals adaptive and maladaptive mechanisms of non-suicidal self-injury.Molecular psychiatry · 2026Article
- Longitudinal changes in control energy of brain networks in older adults at familial risk for Alzheimer's disease.bioRxiv : the preprint server for biology · 2026Article
- Latent brain state dynamics predict early amyloid accumulation and cognitive impairment.bioRxiv : the preprint server for biology · 2026Article
- Dynamic modeling in neurocognitive frameworks of childhood ADHD: a review of inhibitory control and reward systems.Translational psychiatry · 2026Review
- How to Improve Cognitive Flexibility: Evidence From Noninvasive Neuromodulation Techniques.CNS neuroscience & therapeutics · 2025Review
- Brain state dynamics and working memory in patients with schizophrenia and unaffected siblings.BMC medicine · 2025Article
- Disentangling sources of variability in decision-making.Nature reviews. Neuroscience · 2025Review
- Age-associated proteins explain the role of medial temporal lobe networks in Alzheimer's disease.GeroScience · 2025Article
- Common and unique network basis for externally and internally driven flexibility in cognition: From a developmental perspective.Developmental cognitive neuroscience · 2025Article
- Impaired brain ability of older adults to transit and persist to latent states with well-organized structures at wakeful rest.GeroScience · 2025Article
- Dopaminergic modulation and dosage effects on brain state dynamics and working memory component processes in Parkinson's disease.Nature communications · 2025Article
- Altered brain network dynamics and functional connectivity in subjective cognitive decline: an edge-centric network study.Frontiers in aging neuroscience · 2025Article
- Linked patterns of symptoms and cognitive covariation with functional brain controllability in major depressive disorder.EBioMedicine · 2024Article
- A multi-demand operating system underlying diverse cognitive tasks.Nature communications · 2024Article
- Optogenetic stimulation of anterior insular cortex neurons in male rats reveals causal mechanisms underlying suppression of the default mode network by the salience network.Nature communications · 2023Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Cognitive impairment in older adults is a rapidly growing public health concern as the elderly population dramatically grows worldwide. While it is generally assumed that cognitive deficits in older adults are associated with reduced brain flexibility, quantitative evidence has been lacking. Here, we investigate brain flexibility in healthy older adults (ages 60-85) using a novel Bayesian switching dynamical system algorithm and ultrafast temporal resolution (TR = 490 ms) whole-brain fMRI data during performance of a Sternberg working memory task. We identify latent brain states and characterize their dynamic temporal properties, including state transitions, associated with encoding, maintenance, and retrieval. Crucially, we demonstrate that brain inflexibility is associated with slower and more fragmented transitions between latent brain states, and that brain inflexibility mediates the relation between age and cognitive inflexibility. Our study provides a novel neurocomputational framework for investigating latent dynamic circuit processes underlying brain flexibility and cognition in the context of aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.