Evidence map›Paper›PMID 34627824›Full record

ReviewCurrent problems in cardiology2022

Peripheral Artery Disease and COVID-19 Outcomes: Insights from the Yale DOM-CovX Registry.

Kim G Smolderen, Megan Lee, Tanima Arora, Michael Simonov, Carlos Mena-Hurtado

Open access · greenAbstract readReview
In one paragraph

Review in Current problems in cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Guideline
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  13. Distinct Features of Vascular Diseases in COVID-19.Journal of inflammation research · 2023
    Review
  14. Article
  15. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kim G SmolderenDepartment of Internal Medicine, Cardiovascular Medicine Section, Vascular Medicine Outcomes Lab, Yale University, New Haven, CT.
Megan LeeDepartment of Internal Medicine, Cardiovascular Medicine Section, Vascular Medicine Outcomes Lab, Yale University, New Haven, CT.
Tanima AroraDepartment of Internal Medicine, Yale University, New Haven, CT.
Michael SimonovDepartment of Internal Medicine, Yale University, New Haven, CT.
Carlos Mena-HurtadoDepartment of Internal Medicine, Cardiovascular Medicine Section, Vascular Medicine Outcomes Lab, Yale University, New Haven, CT. Electronic address: carlos.mena-hurtado@yale.edu.
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

Both COVID-19 infection and peripheral arterial disease (PAD) cause hypercoagulability in patients, and it remains unknown whether PAD predisposes patients to experience worse outcomes when infected with SARS-CoV-2. The Yale DOM-CovX Registry consecutively enrolled inpatients for SARS-CoV-2 between March 1, 2020, and November 10, 2020. Adjusted logistic regression models examined associations between PAD and mortality, stroke, myocardial infarction (MI), and major adverse cardiovascular events (MACE, all endpoints combined). Of the 3830 patients were admitted with SARS-CoV-2, 50.5% were female, mean age was 63.1 ± 18.4 years, 50.7% were minority race, and 18.3% (n = 693) had PAD. PAD was independently associated with increased mortality (OR = 1.45, 95% CI 1.11-1.88) and MACE (OR = 1.48, 95% CI 1.16-1.87). PAD was not independently associated with stroke (P = 0.06) and MI (P = 0.22). Patients with PAD have a >40% odds of mortality and MACE when admitted with a SARS-CoV-2, independent of known risk factors.

Indexed as

COVID-19Myocardial InfarctionPeripheral Arterial DiseaseStrokeAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedRegistriesRisk FactorsSARS-CoV-2

Identifiers

PMID34627824
PMCPMC8496926
OpenAlexW3205186163

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.