Evidence map›Paper›PMID 34627682›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2021

Pallidal neuron activity determines responsiveness to deep brain stimulation in cervical dystonia.

Alexey Sedov, Valentin Popov, Anna Gamaleya, Ulia Semenova, Alexey Tomskiy, Hyder A Jinnah, Aasef G Shaikh

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Temporal Signature of Task-Specificity in Isolated Focal Laryngeal Dystonia.Movement disorders : official journal of the Movement Disorder Society · 2023
    Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Alexey SedovSemenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia; Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, Russia. Electronic address: alexeyS.sedov@gmail.com.
Valentin PopovSemenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia; N. N. Burdenko National Scientific and Practical Center for Neurosurgery, Moscow, Russia.
Anna GamaleyaN. N. Burdenko National Scientific and Practical Center for Neurosurgery, Moscow, Russia.
Ulia SemenovaSemenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia.
Alexey TomskiyN. N. Burdenko National Scientific and Practical Center for Neurosurgery, Moscow, Russia.
Hyder A JinnahDepartment of Neurology, Pediatrics, and Genetics, Emory University, Atlanta, GA, USA.
Aasef G ShaikhDepartments of Neurology and Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA; Neurological Institute, University Hospitals, Cleveland, OH, USA; Neurology Service, Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA. Electronic address: aasefshaikh@gmail.com.
Burdenko Neurosurgery Institute · RUSemenov Institute of Chemical Physics · RUCase Western Reserve University · USMoscow Institute of Physics and Technology · RUPediatrics and Genetics · US

Funding

Dystonia Coalition- Pilot ProjectU54NS116025 · NINDS · EMORY UNIVERSITY · PI JINNAH, HYDER A · 2019 to 2023
$7.1M
Dystonia CoalitionU54NS065701 · NINDS · EMORY UNIVERSITY · PI JINNAH, HYDER A · 2009 to 2014
$7.0M
Dystonia CoalitionU54TR001456 · NCATS · EMORY UNIVERSITY · PI JINNAH, HYDER A · 2015 to 2016
$2.5M
CSRD VA I01 CX002086NCATS NIH HHS U54 TR001456NINDS NIH HHS U54 NS065701NINDS NIH HHS U54 NS116025
6 · The paper itself

Abstract

objectiveIn patients with cervical dystonia we sought for the differences in neuronal behavior of pallidal regions where deep brain stimulation resulted in favorable therapeutic response compared to those where the response was absent.

methodsWe compared single-unit activity of 564 neurons recorded from deep brain stimulation sensitive and non-sensitive regions in 17 cervical dystonia patients.

resultsGlobus pallidus internus regions responsive to the deep brain stimulation had lower firing rates and bursting compared to non-responsive areas. The differences were robust in locations where neuronal responses correlated with neck movements. Per the effects of deep brain stimulation, the pallidal regions were classified in weak, intermediate, and excellent responsive. Pallidal regions with weak response to deep brain stimulation had fewer burst neurons and higher firing rate compared to neurons in areas with excellent response. The burst index was significantly decreased in excellent response regions. There was a significant decrease in the alpha band oscillation score but a substantial increase in the gamma band in excellent response neurons.

conclusionThe pallidal region that would be responsive to deep brain stimulation has distinct physiology compared to the non-responsive region. SIGNIFICANCE: These results provide novel insights into globus pallidus interna neurons' physiology in cervical dystonia.

Indexed as

Action PotentialsAdultDeep Brain StimulationFemaleGlobus PallidusHumansMaleMiddle AgedNeuronsTorticollisYoung AdultBurst neuronCervical dystoniaDeep brain stimulationGlobus pallidumSingle-unit physiology

Identifiers

PMID34627682
PMCPMC9195244
OpenAlexW3203596200

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.