Evidence map›Paper›PMID 34627312›Full record

ArticleNutrition & metabolism2021

Visceral adiposity index is associated with arterial stiffness in hypertensive adults with normal-weight: the china H-type hypertension registry study.

Junpei Li, Jian Zhu, Ziheng Tan, Yun Yu, Linfei Luo, Wei Zhou, Linjuan Zhu, Tao Wang, Tianyu Cao, Lishun Liu and 3 more

Open access · goldAbstract read
In one paragraph

Article in Nutrition & metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

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  5. Association of maternal body mass index with hemodynamic and vascular alterations at 35-37 weeks' gestation.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025
    Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Junpei LiDepartment of Cardiology, Nanchang University Second Affiliated Hospital, No. 1 Minde Road, Nanchang, 330006, Jiangxi, China.
Jian ZhuQiukou Health Center, Wuyuan, China.
Ziheng TanDepartment of Cardiology, Nanchang University Second Affiliated Hospital, No. 1 Minde Road, Nanchang, 330006, Jiangxi, China.
Yun YuDepartment of Cardiology, Nanchang University Second Affiliated Hospital, No. 1 Minde Road, Nanchang, 330006, Jiangxi, China.
Linfei LuoDepartment of Cardiology, Nanchang University Second Affiliated Hospital, No. 1 Minde Road, Nanchang, 330006, Jiangxi, China.
Wei ZhouDepartment of Cardiology, Nanchang University Second Affiliated Hospital, No. 1 Minde Road, Nanchang, 330006, Jiangxi, China.
Linjuan ZhuDepartment of Cardiology, Nanchang University Second Affiliated Hospital, No. 1 Minde Road, Nanchang, 330006, Jiangxi, China.
Tao WangDepartment of Cardiology, Nanchang University Second Affiliated Hospital, No. 1 Minde Road, Nanchang, 330006, Jiangxi, China.
Tianyu CaoBiological Anthropology, University of California, Santa Barbara, California, USA.
Lishun LiuBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
Huihui BaoDepartment of Cardiology, Nanchang University Second Affiliated Hospital, No. 1 Minde Road, Nanchang, 330006, Jiangxi, China.
Xiao HuangDepartment of Cardiology, Nanchang University Second Affiliated Hospital, No. 1 Minde Road, Nanchang, 330006, Jiangxi, China. drxiaohuang@163.com.
Xiaoshu ChengDepartment of Cardiology, Nanchang University Second Affiliated Hospital, No. 1 Minde Road, Nanchang, 330006, Jiangxi, China. xiaoshumenfan126@163.com.
Second Affiliated Hospital of Nanchang University · CNNanchang University · CNChina Agricultural University · CNUniversity of California, Santa Barbara · US

Funding

5511 Science and Technology Innovation Talent Project of Jiangxi Province 20165BCD41005Jiangxi Outstanding Person Foundation 20192BCBL23024Key R&D Projects, Jiangxi 20203BBGL73173Key Technologies Research and Development Program 2018YFC1312902National Natural Science Foundation of China 81760049National Natural Science Foundation of China 81960074
6 · The paper itself

Abstract

backgroundLimited information is available on arterial stiffness risk among hypertensive patients with metabolically abnormal but normal weight. Visceral adiposity index (VAI) is a novel indicator for visceral fat mass and metabolism, however, whether can be used to assessed arterial stiffness in a normal-weight population remains unclear. The goal of this study was to examine the independent association of VAI with arterial stiffness in normal-weight hypertensive patients.

methods3258 participants recruited from the China H-type Hypertension Registry Study. VAI value was calculated using sex-specific equations. High arterial stiffness was defined as baPWV ≥ 18 m/s. Multivariable regression analysis was used to identify the association of VAI with baPWV and high arterial stiffness.

resultsOf participants, 50.5% (1644) were males, the mean age was 65.5 (SD, 9.1) years. Mean VAI and baPWV were 2.0 (SD, 2.3) and 18.2 (SD, 3.9) m/s, respectively. For each unit increase of lg VAI in multivariable regression analysis, there was a 1.05 m/s increase in baPWV (95% CI 0.67, 1.43) and a 2.13-fold increase in the risk of high arterial stiffness (95% CI 1.59, 2.86). In all models, the VAI was consistently and significantly associated with baPWV after adjustment for different confounders. High VAI levels were stably associated with baPWV in all subgroups.

conclusionsWe found positive association of VAI with baPWV and high arterial stiffness in normal-weight adults with hypertension. The establishment of this association could help the arterial stiffness risk stratification in normal-weight hypertensive populations, who are frequently overlooked in preventing cardiovascular disease.

Indexed as

Body mass indexBrachial-ankle pulse wave velocityHypertensionNormal weightVisceral adiposity index

Identifiers

PMID34627312
PMCPMC8502385
OpenAlexW3207611025

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.