Evidence map›Paper›PMID 34627274›Full record

ArticleJournal of translational medicine2021

Regional brain tissue changes in patients with cystic fibrosis.

Bhaswati Roy, Marlyn S Woo, Susana Vacas, Patricia Eshaghian, Adupa P Rao, Rajesh Kumar

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Cystic Fibrosis-related neurodegenerative disease associated with tauopathy and cognitive decline in aged CF mice.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2025
    Article
  3. Managing an ageing cystic fibrosis population: challenges and priorities.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  4. Article
  5. The ageing of people living with cystic fibrosis: what to expect now?European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Bhaswati RoyDepartment of Anesthesiology and Perioperative Medicine, University of California at Los Angeles, Los Angeles, CA, 90095, USA.
Marlyn S WooDepartment of Pediatric Pulmonology, University of California at Los Angeles, Los Angeles, CA, 90095, USA.
Susana VacasDepartment of Anesthesiology and Perioperative Medicine, University of California at Los Angeles, Los Angeles, CA, 90095, USA.
Patricia EshaghianDepartment of Medicine, University of California at Los Angeles, Los Angeles, CA, 90095, USA.
Adupa P RaoDepartment of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA.
Rajesh KumarDepartment of Anesthesiology and Perioperative Medicine, University of California at Los Angeles, Los Angeles, CA, 90095, USA. rkumar@mednet.ucla.edu.
University of California, Los Angeles · USUniversity of Southern California · US

Funding

Mechanisms Mediating Postoperative Neurocognitive DisordersK23GM132795 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VACAS, SUSANA · 2019 to 2023
$1.0M
Blood Brain Barrier Dysfunction and Perioperative Neurocognitive Disorders in older adultsR21AG070269 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUMAR, RAJESH, VACAS, SUSANA · 2020 to 2020
$429k
NIA NIH HHS R21 AG070269NIGMS NIH HHS K23 GM132795NIH HHS K23GM132795NIH HHS R21 AG070269
6 · The paper itself

Abstract

backgroundCystic fibrosis (CF) patients present with a variety of symptoms, including mood and cognition deficits, in addition to classical respiratory, and autonomic issues. This suggests that brain injury, which can be examined with non-invasive magnetic resonance imaging (MRI), is a manifestation of this condition. However, brain tissue integrity in sites that regulate cognitive, autonomic, respiratory, and mood functions in CF patients is unclear. Our aim was to assess regional brain changes using high-resolution T1-weighted images based gray matter (GM) density and T2-relaxometry procedures in CF over control subjects.

methodsWe acquired high-resolution T1-weighted images and proton-density (PD) and T2-weighted images from 5 CF and 15 control subjects using a 3.0-Tesla MRI. High-resolution T1-weighted images were partitioned to GM-tissue type, normalized to a common space, and smoothed. Using PD- and T2-weighted images, whole-brain T2-relaxation maps were calculated, normalized, and smoothed. The smoothed GM-density and T2-relaxation maps were compared voxel-by-voxel between groups using analysis of covariance (covariates, age and sex; SPM12, p < 0.001).

resultsSignificantly increased GM-density, indicating tissues injury, emerged in multiple brain regions, including the cerebellum, hippocampus, amygdala, basal forebrain, insula, and frontal and prefrontal cortices. Various brain areas showed significantly reduced T2-relaxation values in CF subjects, indicating predominant acute tissue changes, in the cerebellum, cerebellar tonsil, prefrontal and frontal cortices, insula, and corpus callosum.

conclusionsCystic fibrosis subjects show predominant acute tissue changes in areas that control mood, cognition, respiratory, and autonomic functions and suggests that tissue changes may contribute to symptoms resulting from ongoing hypoxia accompanying the condition.

Indexed as

Cystic FibrosisBrainBrain MappingGray MatterHumansMagnetic Resonance ImagingCognitionGray matter densityMagnetic resonance imagingMoodT2-relaxometery

Identifiers

PMID34627274
PMCPMC8502335
OpenAlexW3191538486

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.