ArticleLipids in health and disease2021
Association of lipid accumulation product with chronic kidney disease in Chinese community adults: a report from the REACTION study.
Article in Lipids in health and disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 20 citations in OpenAlex.
- Article
- Association of cholesterol, high-density lipoprotein, and glucose (CHG) index with chronic kidney disease in Chinese community adults: findings from the REACTION study.Frontiers in nutrition · 2026Article
- When Obesity Hits the Kidneys: Sex-Specific Effects of Visceral Adiposity Indices on Diabetic Kidney Disease Risk.Journal of nutrition and metabolism · 2026Article
- Lipid accumulation product index is inversely U-shaped associated with abdominal aortic calcification based on NHANES 2013-2014.Frontiers in cardiovascular medicine · 2025Article
- Association between the lipid accumulation product and chronic kidney disease among adults in the United States.Scientific reports · 2024Article
- Association between lipid accumulation product index and chronic kidney disease: A systematic review and meta-analysis.Experimental and therapeutic medicine · 2024Article
- Associations between metabolic profiles and incident CKD in the Chinese population aged 45-85 years.International urology and nephrology · 2024Article
- Lipid accumulation product, poverty income ratio, and bone mineral density in U.S. adults: a mediation analysis based on NHANES (2009-2020).Frontiers in nutrition · 2024Article
- Associations of serum carotenoids with visceral adiposity index and lipid accumulation product: a cross-sectional study based on NHANES 2001-2006.Lipids in health and disease · 2023Article
- The new visceral adiposity index outperforms traditional obesity indices as a predictor of subclinical renal damage in Chinese individuals: a cross-sectional study.BMC endocrine disorders · 2023Article
- Positive correlation between lipid accumulation product index and arterial stiffness in Chinese patients with type 2 diabetes.Frontiers in endocrinology · 2023Article
- Metabolic Syndrome and Obesity-Related Indices Are Associated with Rapid Renal Function Decline in a Large Taiwanese Population Follow-Up Study.Biomedicines · 2022Article
- Lipid Accumulation Product Index Predicts New-Onset Type 2 Diabetes Among Non-Obese Koreans: A 12-Year Longitudinal Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
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Authors and funding
9 authors at 2 institutions in 1 country.
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Abstract
backgroundLimited studies regarding the correlation of lipid accumulation product (LAP) with a decreased estimated glomerular filtration rate (eGFR) have yielded conflicting findings, and no report has demonstrated the relationship of LAP with chronic kidney disease (CKD), defined as the presence of albuminuria and/or a decreased eGFR. The purpose of this study was to estimate the possible correlation of LAP with CKD prevalence in Chinese community adults.
methodIn this cross-sectional study, LAP level of 7202 participants (age ≥ 40 years) was determined, and its possible association with CKD was evaluated by a multiple logistic regression model.
resultsCompared with subjects with non-CKD, non-albuminuria, and high eGFR, LAP levels significantly increased in female not male subjects with CKD, albuminuria, and low eGFR, respectively (all P < 0.001). The univariate logistic regression analysis revealed that LAP level of female not male subjects were significantly and positively associated with the prevalence of CKD (P < 0.001). The multivariate logistic regression analysis showed that the risk of CKD prevalence in female not male subjects progressively increased across LAP quartiles (P for trend < 0.01), and the risk of CKD prevalence of subjects in Q4 significantly increased compared to those in Q1 after adjustment for potential confounding factors in Models 4 (odds ratio [OR]: 1.382, 95% confidence intervals [CI] 1.002-1.906, P < 0.05). Stratified analysis revealed positive associations of LAP quartiles with risk of CKD prevalence in people with the following characteristics: women, older, overweight, with hypertension, normal glucose tolerance, appropriate low-density lipoprotein cholesterol, nonsmokers, nondrinkers, and no cardiovascular disease events.
conclusionsHigh LAP levels might be significantly associated with risk of CKD prevalence in community-dwelling Chinese female adults, which may inform both public health recommendations and clinical practice.
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