Evidence map›Paper›PMID 34627266›Full record

ArticleJournal of nanobiotechnology2021

Simvastatin induced ferroptosis for triple-negative breast cancer therapy.

Xianxian Yao, Ruihong Xie, Yongbin Cao, Jing Tang, Yongzhi Men, Haibao Peng, Wuli Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
132citing papers in PubMed, 5 pooled it
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

132 citing papers in PubMed, 5 syntheses or guidelines pooled it, 214 citations in OpenAlex.

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  5. The association of statin therapy and cancer: a meta-analysis.Lipids in health and disease · 2023 · on this map
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72 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Xianxian YaoState Key Laboratory of Molecular Engineering of Polymers & Department of Macromolecular Science, Fudan University, Shanghai, 200433, China.
Ruihong XieState Key Laboratory of Molecular Engineering of Polymers & Department of Macromolecular Science, Fudan University, Shanghai, 200433, China.
Yongbin CaoState Key Laboratory of Molecular Engineering of Polymers & Department of Macromolecular Science, Fudan University, Shanghai, 200433, China.
Jing TangDepartment of Materials Science and Engineering, Stanford University, Stanford, CA, USA.
Yongzhi MenShanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
Haibao PengInstitute for Translational Brain Research, Fudan University, Shanghai, 200032, China. haibaopeng@gmail.com.ORCID http://orcid.org/0000-0003-4587-0977
Wuli YangState Key Laboratory of Molecular Engineering of Polymers & Department of Macromolecular Science, Fudan University, Shanghai, 200433, China. wlyang@fudan.edu.cn.
Fudan University · CNShanghai Jiao Tong University · CNStanford University · US

Funding

national natural science foundation of china 51873041national natural science foundation of china 81902756national natural science foundation of china Grant Nos. 51933002program of shanghai academic research leader 20XD1400400shanghai sailing program No.19Y1439900the open project of state key laboratory of molecular engineering of polymers No. K2021-19
6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC), a management of aggressive breast cancer, remains an unmet medical challenge. Although a wave of efforts had spurred to design novel therapeutic method of TNBC, unpredictable prognosis with lacking effective therapeutic targets along with the resistance to apoptosis seriously limited survival benefits. Ferroptosis is a non-apoptotic form of cell death that is induced by excessive lipid peroxidation, which provide an innovative way to combat cancer. Emerging evidence suggests that ferroptosis plays an important role in the treatment of TNBC cells. Herein, a novel ferroptosis nanomedicine was prepared by loading simvastatin (SIM), a ferroptosis drug, into zwitterionic polymer coated magnetic nanoparticles (Fe

Indexed as

SimvastatinAnimalsCell Line, TumorDelayed-Action PreparationsDrug CarriersFemaleFerroptosisHumansMagnetite NanoparticlesMCF-7 CellsMiceMice, NudeSignal TransductionTriple Negative Breast NeoplasmsDelayed-Action PreparationsDrug CarriersMagnetite NanoparticlesSimvastatinControlled releaseFerroptosisLong circulationSimvastatinTriple-negative breast cancer

Identifiers

PMID34627266
PMCPMC8502296
OpenAlexW3206510813

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.