Evidence map›Paper›PMID 34627157›Full record

ArticleBMC geriatrics2021

Associations of changes in late-life blood pressure with cognitive impairment among older population in China.

Hui Gao, Kan Wang, Fariba Ahmadizar, Jianlin Zhuang, Yu Jiang, Lei Zhang, Jialing Gu, Wensui Zhao, Zhao-Lin Xia

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC geriatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Hui Gao *Changning Center for Disease Control and Prevention, P.O. Box 803, 39 Yunwushan Road, Shanghai, 200032, China.
Kan Wang *Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Fariba AhmadizarDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Jianlin ZhuangChangning Center for Disease Control and Prevention, P.O. Box 803, 39 Yunwushan Road, Shanghai, 200032, China.
Yu JiangChangning Center for Disease Control and Prevention, P.O. Box 803, 39 Yunwushan Road, Shanghai, 200032, China.
Lei ZhangChangning Center for Disease Control and Prevention, P.O. Box 803, 39 Yunwushan Road, Shanghai, 200032, China.
Jialing GuChangning Center for Disease Control and Prevention, P.O. Box 803, 39 Yunwushan Road, Shanghai, 200032, China.
Wensui ZhaoChangning Center for Disease Control and Prevention, P.O. Box 803, 39 Yunwushan Road, Shanghai, 200032, China. zhaowensui@cncdc.org.
Zhao-Lin XiaSchool of Public Health, & Key Laboratory of Public Health Safety of Ministry of Education of China, Fudan University, Shanghai, 200032, China.
Shanghai Municipal Center For Disease Control Prevention · CNErasmus MC · NLFudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe cognitive impact of changes in late-life blood pressure is less clear. We aimed to investigate the association between late-life blood pressure changing pattern and risk of cognitive impairment.

methodsUsing data from the community-based Chinese Longitudinal Healthy Longevity Survey, change in systolic (SBP) or diastolic (DBP) blood pressure was calculated as the difference between follow-up and baseline, cognitive impairment was defined based on both the Mini-Mental State Examination and education level. The generalized additive model with penalized spline and multivariate logistic regression model were used, respectively, to examine the associations between continuous and categorized blood pressure changes with cognitive impairment at the follow-up wave.

resultsA total of 8493 Chinese elderly without cognitive impairment were included, with mean (standard deviation) age 80.6 (10.7) years. U-shaped associations between late-life blood pressure changes and risk of cognitive impairment were found, with only stable optimal blood pressure related to the lowest risk. For participants with baseline SBP around 130-150 mmHg, the adjusted odds ratio was 1.48 (1.13-1.93) for increasing follow-up SBP (> 150 mmHg), 1.28 (1.02-1.61) for decreasing follow-up SBP (< 130 mmHg), compared to stable follow-up SBP (130-150 mmHg). For participants with relative lower baseline DBP (< 80 mmHg), increasing their DBP to 80-90 mmHg during follow-up was associated with lower cognitive impairment risk (0.73 (0.58-0.93)), compared to steady low follow-up DBP (< 80 mmHg). Sex-specific analysis suggested that men were more vulnerable in term of SBP change.

conclusionsAdhering to a stable optimal level of blood pressure in late-life is related to lower risk of cognitive impairment in Chinese elderly.

Indexed as

Cognitive DysfunctionHypertensionAgedAged, 80 and overBlood PressureChinaFemaleHumansLongitudinal StudiesMaleOdds RatioChanges of blood pressureCognitive functionElderly

Identifiers

PMID34627157
PMCPMC8501650
OpenAlexW3207954094

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.