Evidence map›Paper›PMID 34627139›Full record

ArticleBMC bioinformatics2021

CorDiffViz: an R package for visualizing multi-omics differential correlation networks.

Shiqing Yu, Mathias Drton, Daniel E L Promislow, Ali Shojaie

Abstract read
In one paragraph

Article in BMC bioinformatics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shiqing YuDepartment of Statistics, University of Washington, NE Stevens Way, Seattle, WA, 98195, USA. syu.phd@gmail.com.ORCID http://orcid.org/0000-0002-2719-7558
Mathias DrtonDepartment of Mathematics, Technical University of Munich, Boltzmannstraße, 85748, Garching bei München, Germany.
Daniel E L PromislowDepartments of Pathology and Biology, University of Washington, NE Pacific St, Seattle, WA, 98195, USA.
Ali ShojaieDepartment of Biostatistics, University of Washington, NE Pacific St, Seattle, WA, 98195, USA.

Funding

Metabolome-Genome Associations for Determining Mechanisms of Aging in DrosophilaR01AG049494 · NIA · UNIVERSITY OF WASHINGTON · PI PROMISLOW, DANIEL EDWARD · 2015 to 2019
$1.8M
Machine Learning Tools for Discovery and Analysis of Active Metabolic PathwaysR01GM114029 · NIGMS · UNIVERSITY OF WASHINGTON · PI SHOJAIE, ALI · 2016 to 2020
$1.7M
Novel Statistical Inference for Biomedical Big DataR01GM133848 · NIGMS · UNIVERSITY OF WASHINGTON · PI SHOJAIE, ALI · 2020 to 2023
$1.7M
National Science Foundation DMS/NIGMS-1561814NIA NIH HHS R01 AG049494NIA NIH HHS R01-AG049494NIGMS NIH HHS R01 GM114029NIGMS NIH HHS R01-GM114029NIGMS NIH HHS R01 GM133848
6 · The paper itself

Abstract

backgroundDifferential correlation networks are increasingly used to delineate changes in interactions among biomolecules. They characterize differences between omics networks under two different conditions, and can be used to delineate mechanisms of disease initiation and progression.

resultsWe present a new R package, CorDiffViz, that facilitates the estimation and visualization of differential correlation networks using multiple correlation measures and inference methods. The software is implemented in R, HTML and Javascript, and is available at https://github.com/sqyu/CorDiffViz . Visualization has been tested for the Chrome and Firefox web browsers. A demo is available at https://diffcornet.github.io/CorDiffViz/demo.html .

conclusionsOur software offers considerable flexibility by allowing the user to interact with the visualization and choose from different estimation methods and visualizations. It also allows the user to easily toggle between correlation networks for samples under one condition and differential correlations between samples under two conditions. Moreover, the software facilitates integrative analysis of cross-correlation networks between two omics data sets.

Indexed as

SoftwareWeb BrowserCorrelation networksData integrationDifferential correlationsOmicsUndirected graphsVisualization

Identifiers

PMID34627139
PMCPMC8501646

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.