Evidence map›Paper›PMID 34626893›Full record

ArticlePlacenta2021

Seroprevalence of SARS-CoV-2 immunoglobulins in pregnant women and neonatal cord blood from a highly impacted region.

Hector Zambrano, Ketty Anchundia, Dalila Aviles, Ruffo Andaluz, Nathaly Calderon, Estefanie Torres, Nicolas Gonzalez-Granda, Anthony Maxwell, Kang Chen, Bernard Gonik and 1 more

Open access · greenAbstract read
In one paragraph

Article in Placenta, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Hector ZambranoECUAGENOMA, SA, Guayaquil, Ecuador.
Ketty AnchundiaECUAGENOMA, SA, Guayaquil, Ecuador.
Dalila AvilesECUAGENOMA, SA, Guayaquil, Ecuador.
Ruffo AndaluzCGORA WOMEN CLINIC, Babahoyo, Ecuador.
Nathaly CalderonECUAGENOMA, SA, Guayaquil, Ecuador.
Estefanie TorresECUAGENOMA, SA, Guayaquil, Ecuador.
Nicolas Gonzalez-GrandaECUAGENOMA, SA, Guayaquil, Ecuador.
Anthony MaxwellC.S. Mott Center for Human Growth and Development, Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA.
Kang ChenC.S. Mott Center for Human Growth and Development, Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA.
Bernard GonikC.S. Mott Center for Human Growth and Development, Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA.
Gil MorC.S. Mott Center for Human Growth and Development, Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA. Electronic address: gmor@med.wayne.edu.
Wayne State University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Mechanisms of trophoblast-induced immune modulationR01AI145829 · NIAID · WAYNE STATE UNIVERSITY · PI MOR, GIL G · 2019 to 2023
$1.9M
NCATS NIH HHS UL1 TR001863NIAID NIH HHS R01 AI145829
6 · The paper itself

Abstract

There is inadequate screening for SARS-COV-2 during pregnancy. We aimed to determine the impact of maternal and neonatal cord blood SARS-COV-2 antibodies and placental transfer ratios in a region with a low screening plan. We performed a blind study in one of the SARS-CoV-2 epicenters in South America. 32% of pregnant women were serological positive. Importantly, there is an efficient passive immunization of the fetus to SARS-CoV-2. We report high incidence of SARS-CoV-2 infection during pregnancy, which is higher than officially reported. Therefore the need of active immunization to enhance maternal protection and fetal passive immunization.

Indexed as

AdolescentAdultAntibodies, ViralCOVID-19EcuadorFemaleFetal BloodHumansImmunization, PassiveImmunoglobulin GImmunoglobulin MIncidenceInfant, NewbornInfectious Disease Transmission, VerticalMaleMiddle AgedAntibodies, ViralImmunoglobulin GImmunoglobulin MIgGIgMPlacentaPregnancySARS-COV-2

Identifiers

PMID34626893
PMCPMC8492380
OpenAlexW3203358325

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.