ReviewBrazilian journal of anesthesiology (Elsevier)
Clinical use of tranexamic acid: evidences and controversies.
Review in Brazilian journal of anesthesiology (Elsevier). The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 36 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Topical Tranexamic Acid on Postoperative Drainage in Minimally Invasive Transforaminal Lumbar Interbody Fusion (MI-TLIF): A Randomized Controlled Trial
The Effect of Local and Systemic Tranexamic Acid on Edema and Ecchymosis in Orbital Surgery - a Prospective, Multicenter, Randomized, Double-blinded, Control Trial
Efficacy of Tranexamic Acid Reducing Blood Loss During Maxillofacial Trauma Surgery
Who cites it
36 citing papers in PubMed, 5 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Evaluation of the Safety and Efficacy of Tranexamic Acid Use in Blepharoplasty: A Systematic Review of Randomized Controlled Trials.Aesthetic plastic surgery · 2026Pooled it
- Tranexamic acid can reduce blood loss and improve visibility in otological surgeries: a systematic review and meta-analysis of randomised controlled trials.The Journal of laryngology and otology · 2025Pooled it
- Evaluating Tranexamic Acid's Role in Upper Eyelid Blepharoplasty: A Systematic Review and Meta-Analysis.Aesthetic plastic surgery · 2025Pooled it
- Tranexamic acid-induced anaphylaxis: a systematic review.European journal of clinical pharmacology · 2025Pooled it
- Efficacy of tranexamic acid application in gynecology and obstetrics procedures: a umbrella review of systematic reviews of randomized trials.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2025Pooled it
- Effect of Prophylactic Intraoperative Tranexamic Acid on Postpartum Blood Loss Following Cesarean Section at a Single Center.Medical science monitor : international medical journal of experimental and clinical research · 2025Trial
- Trial
- Effect of Tranexamic Acid to Reduce Postoperative Hematoma in Reduction Mammaplasty: A Retrospective Analysis of 656 Patients.Aesthetic plastic surgery · 2026Article
- Interpretable Machine Learning Analysis of Factors Associated with Postoperative Hemoglobin Reduction After Total Knee Arthroplasty: A Standardized-Protocol Cohort Study in Non-Transfused Patients.Journal of clinical medicine · 2026Article
- Association Between Complications and Death Within 30 Days After Orthopedic Surgery: Vascular Events in Noncardiac Surgery Patients Cohort Evaluation (VISION) Substudy.JMIR perioperative medicine · 2026Article
- Influence of Antithrombotics on Severely Injured Patients Over 50 With Blunt Abdominal Trauma.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Efficacy of postoperative tranexamic acid administration in patients undergoing proximal femoral tumor endoprosthesis reconstruction.Perioperative medicine (London, England) · 2026Article
- Article
- Perioperative Tranexamic Acid Reduces Bleeding and Wound Complications in Post-Bariatric Abdominoplasty: A Retrospective Cohort Study.Life (Basel, Switzerland) · 2026Article
- Triple-dose bolus versus continuous infusion of tranexamic acid: impacts on clinical outcomes in isolated coronary artery bypass surgery.Journal of cardiothoracic surgery · 2026Observational
- Effect of Routes of Administration of Tranexamic Acid in Peri-Operative Blood Loss in Total Hip Arthroplasty: A Prospective Comparative Study.Journal of orthopaedic case reports · 2026Article
- Intravenous Tranexamic Acid Reduces the Incidence of Postoperative Delirium in Elderly Patients Undergoing Hip Arthroplasty: A Retrospective Cohort Study.Drug design, development and therapy · 2026Article
- Tranexamic acid does not have a dose-dependent effect on postoperative delirium after cardiac surgery - a retrospective cohort study.The journal of extra-corporeal technology · 2025Observational
- Systemic Administration of Tranexamic Acid Improves Postoperative Outcome in Abdominoplasty.Journal of clinical medicine · 2025Article
- Stealth hemostatic anchors with vWF-driven navigation and plasmin-triggered tranexamic release for hematoma containment in cerebral hemorrhage.Asian journal of pharmaceutical sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tranexamic acid (TXA) significantly reduces blood loss in a wide range of surgical procedures and improves survival rates in obstetric and trauma patients with severe bleeding. Although it mainly acts as a fibrinolysis inhibitor, it also has an anti-inflammatory effect, and may help attenuate the systemic inflammatory response syndrome found in some cardiac surgery patients. However, the administration of high doses of TXA has been associated with seizures and other adverse effects that increase the cost of care, and the administration of TXA to reduce perioperative bleeding needs to be standardized. Tranexamic acid is generally well tolerated, and most adverse reactions are considered mild or moderate. Severe events are rare in clinical trials, and literature reviews have shown tranexamic acid to be safe in several different surgical procedures. However, after many years of experience with TXA in various fields, such as orthopedic surgery, clinicians are now querying whether the dosage, route and interval of administration currently used and the methods used to control and analyze the antifibrinolytic mechanism of TXA are really optimal. These issues need to be evaluated and reviewed using the latest evidence to improve the safety and effectiveness of TXA in treating intracranial hemorrhage and bleeding in procedures such as liver transplantation, and cardiac, trauma and obstetric surgery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.