Evidence map›Paper›PMID 34626686›Full record

SynthesisNeuroscience and biobehavioral reviews2021

Heart rate variability as a biomarker of functional outcomes in persons with acquired brain injury: Systematic review and meta-analysis.

Yejin Lee, Ryan J Walsh, Mandy W M Fong, Marek Sykora, Michelle M Doering, Alex W K Wong

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Neuroscience and biobehavioral reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. The Roles of Heart Rate Variability in Cerebral Stroke.Neuropsychiatric disease and treatment · 2025
    Review
  10. Article
  11. Article
  12. The ECG abnormalities in persons with chronic disorders of consciousness.Medical & biological engineering & computing · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yejin LeeProgram in Occupational Therapy, Washington University School of Medicine, St. Louis, MO, 63110, USA. Electronic address: yejin.l@wustl.edu.
Ryan J WalshProgram in Occupational Therapy, Washington University School of Medicine, St. Louis, MO, 63110, USA. Electronic address: rjwalsh@wustl.edu.
Mandy W M FongDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, 63108, USA. Electronic address: wfong@wustl.edu.
Marek SykoraDepartment of Neurology, St. John's Hospital, Vienna, Austria; Medical Faculty, Sigmund Freud University, Vienna, Austria; Department of Neurology, Comenius University in Bratislava, Bratislava, Slovakia. Electronic address: mareksykora@yahoo.com.
Michelle M DoeringBernard Becker Medical Library, Washington University School of Medicine, St. Louis, MO, 63110, USA. Electronic address: mmdoering@wustl.edu.
Alex W K WongCenter for Rehabilitation Outcomes Research, Shirley Ryan AbilityLab, Chicago, IL, 60611, USA; Department of Physical Medicine and Rehabilitation and Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA. Electronic address: wwong@sralab.org.

Funding

Technology Development ComponentP2CHD101899 · NICHD · REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB · PI LIEBER, RICHARD L. · 2020 to 2024
$5.6M
Mobile Rehabilitation for Daily Life Participation Post-StrokeK01HD095388 · NICHD · WASHINGTON UNIVERSITY · PI WONG, WING KAI · 2019 to 2023
$642k
NICHD NIH HHS K01 HD095388NICHD NIH HHS P2C HD101899
6 · The paper itself

Abstract

This review aimed to quantify correlations between heart rate variability (HRV) and functional outcomes after acquired brain injury (ABI). We conducted a literature search from inception to January 2020 via electronic databases, using search terms with HRV, ABI, and functional outcomes. Meta-analyses included 16 studies with 906 persons with ABI. Results demonstrated significant associations: Low frequency (LF) (r = -0.28) and SDNN (r = -0.33) with neurological function; LF (r = -0.33), High frequency (HF) (r = -0.22), SDNN (r = -0.22), and RMSSD (r = -0.23) with emotional function; and LF (r = 0.34), HF (r = 0.41 to 0.43), SDNN (r = 0.43 to 0.51), and RMSSD (r = 0.46) with behavioral function. Results indicate that higher HRV is related to better neurological, emotional, and behavioral functions after ABI. In addition, persons with stroke showed lower HF (SMD = -0.50) and SDNN (SMD = -0.75) than healthy controls. The findings support the use of HRV as a biomarker to facilitate precise monitoring of post-ABI functions.

Indexed as

Brain InjuriesEmotionsBiomarkersHeart RateHumansBiomarkersBiomarkerBrain injuriesFunctional outcomesHeart rate variabilityMeta-analysisOutcome assessment (health care)Stroke

Identifiers

PMID34626686
PMCPMC9006352

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.