Evidence map›Paper›PMID 34626672›Full record

Trial reportThe Journal of pediatrics2022

Do Extremely Low Gestational Age Neonates Regulate Iron Absorption via Hepcidin?

Kendell R German, Bryan A Comstock, Pratik Parikh, Dale Whittington, Dennis E Mayock, Patrick J Heagerty, Timothy M Bahr, Sandra E Juul

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06555315 (Pilot Non-inferiority Study Investigating Daily Versus Every Other Day Dosing of Oral Iron in Premature Infants.), which is not on this map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06555315 narecruitingnot on this mapstarted 2024, after this paper: background citation

Pilot Non-inferiority Study Investigating Daily Versus Every Other Day Dosing of Oral Iron in Premature Infants.

TypeinterventionalSponsorCHRISTUS HealthRan2024 to 2026Enrolled100ConditionsVery Low Birth Weight Infant, Premature Infants, Anemia of Prematurity, Iron Deficiency, Anaemia in ChildrenArms6 mg/kg of oral iron as ferrous sulfate administered every other day., 6 mg/kg of oral iron as ferrous sulfate administered every day.
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Observational
  4. Review
  5. Article
  6. Anemia, Iron Supplementation, and the Brain.Clinics in perinatology · 2023
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Kendell R GermanDepartment of Pediatrics, University of Washington, Seattle, WA. Electronic address: germank@uw.edu.
Bryan A ComstockDepartment of Biostatistics, University of Washington, Seattle, WA.
Pratik ParikhDepartment of Pediatrics, Baylor College of Medicine, Children's Hospital of San Antonio, San Antonio, TX.
Dale WhittingtonDepartment of Medicinal Chemistry, University of Washington, Seattle, WA.
Dennis E MayockDepartment of Pediatrics, University of Washington, Seattle, WA.
Patrick J HeagertyDepartment of Biostatistics, University of Washington, Seattle, WA.
Timothy M BahrDepartment of Pediatrics, University of Utah, Salt Lake City, UT.
Sandra E JuulDepartment of Pediatrics, University of Washington, Seattle, WA.
University of Washington · USBaylor College of Medicine · USUniversity of Utah · US

Funding

Preterm Epo Neuroprotection Trial (PENUT Trial) CCCU01NS077953 · NINDS · UNIVERSITY OF WASHINGTON · PI JUUL, SANDRA E · 2013 to 2018
$10.7M
Preterm Epo Neuroprotection Trial (PENUT Trial) DCCU01NS077955 · NINDS · UNIVERSITY OF WASHINGTON · PI HEAGERTY, PATRICK J · 2013 to 2018
$1.5M
NINDS NIH HHS U01 NS077953NINDS NIH HHS U01 NS077955
6 · The paper itself

Abstract

objectivesTo evaluate whether extremely preterm infants regulate iron status via hepcidin. STUDY

designIn this retrospective analysis of infants from the Preterm Epo Neuroprotection (PENUT) Trial, urine hepcidin (Uhep) normalized to creatinine (Uhep/UCr) was evaluated among infants randomized to erythropoietin (Epo) or placebo.

resultsThe correlation (r) between Uhep/UCr and serum markers of iron status (ferritin and zinc protoporphyrin-to-heme ratio [ZnPP/H]) and iron dose was assessed. A total of 243 urine samples from 76 infants born at 24-27

conclusionsUhep/UCr values correlate with serum iron markers. Uhep/UCr values vary over time and are affected by treatment with Epo, suggesting that extremely preterm neonates can regulate hepcidin and therefore their iron status. Uhep is suppressed in extremely preterm neonates, particularly those treated with Epo.

Indexed as

BiomarkersCreatinineErythropoietinFerritinsHemeHepcidinsHumansInfantInfant, Extremely PrematureInfant, NewbornIronProtoporphyrinsRetrospective StudiesBiomarkersCreatinineErythropoietinFerritinsHemeHepcidinsIronProtoporphyrinszinc protoporphyrinferritinhepcidinironpretermzinc protoporphyrin-to-heme ratio

Identifiers

PMID34626672
PMCPMC8792194
OpenAlexW3202078422

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.