Evidence map›Paper›PMID 34626671›Full record

ArticleThe Journal of pediatrics2022

Defining the Healthy Infant Metabolome: Liquid Chromatography Tandem-Mass Spectrometry Analysis of Dried Blood Spot Extracts from the Prospective Research on Early Determinants of Illness and Children's Health Trajectories Birth Cohort Study.

William S Schleif, Robert S Harlan, Frances Hamblin, Ernest K Amankwah, Neil A Goldenberg, Raquel G Hernandez, Sara B Johnson, Shannon Reed, David R Graham

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The Multi-Omic Approach to Newborn Screening: Opportunities and Challenges.International journal of neonatal screening · 2024
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

William S SchleifJohns Hopkins All Children's Pediatric Biorepository, Johns Hopkins All Children's Hospital, St Petersburg, FL; Pediatric Biospecimen Science Program, Johns Hopkins All Children's Institute for Clinical and Translational Research, St Petersburg, FL.
Robert S HarlanJohns Hopkins Molecular Determinants Center and Core, Johns Hopkins All Children's Hospital, St Petersburg, FL; Johns Hopkins University School of Medicine, Baltimore, MD.
Frances HamblinClinical Coordinating Center, Johns Hopkins All Children's Institute for Clinical and Translational Research, St Petersburg, FL.
Ernest K AmankwahData Coordinating Center, Johns Hopkins All Children's Institute for Clinical and Translational Research, St Petersburg, FL; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Oncology, Johns Hopkins University School of Medicine, St Petersburg, FL.
Neil A GoldenbergPediatric Biospecimen Science Program, Johns Hopkins All Children's Institute for Clinical and Translational Research, St Petersburg, FL; Clinical Coordinating Center, Johns Hopkins All Children's Institute for Clinical and Translational Research, St Petersburg, FL; Data Coordinating Center, Johns Hopkins All Children's Institute for Clinical and Translational Research, St Petersburg, FL; Pediatric Health Equity Research Program, Johns Hopkins All Children's Institute for Clinical and Translational Research, St Petersburg, FL; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Raquel G HernandezPediatric Health Equity Research Program, Johns Hopkins All Children's Institute for Clinical and Translational Research, St Petersburg, FL; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD.
Sara B JohnsonDepartment of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD.
Shannon ReedJohns Hopkins Molecular Determinants Center and Core, Johns Hopkins All Children's Hospital, St Petersburg, FL.
David R GrahamPediatric Biospecimen Science Program, Johns Hopkins All Children's Institute for Clinical and Translational Research, St Petersburg, FL; Johns Hopkins Molecular Determinants Center and Core, Johns Hopkins All Children's Hospital, St Petersburg, FL; Department of Anesthesia and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address: dgraham@jhmi.edu.

Funding

Social adversities, epigenetics, and the obesity epidemicR01MD011746 · NIMHD · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI HOYO, CATHRINE · 2017 to 2021
$4.4M
NIMHD NIH HHS R01 MD011746
6 · The paper itself

Abstract

Newborn screening using dried plasma spots offers preanalytical advantages over conventional cards for plasma-associated targets of interest. Herein we present dried plasma spot-based methods for measuring metabolites using a 250+ compound liquid chromatography tandem mass spectrometry library. Quality assurance reduced this library to 134, and from these, 30 compounds determined the normal newborn reference ranges.

Indexed as

Chromatography, LiquidMetabolomeTandem Mass SpectrometryBiomarkersBlood PreservationDried Blood Spot TestingFemaleHumansInfantInfant, NewbornMaleNeonatal ScreeningProspective StudiesReference ValuesSpecimen HandlingBiomarkers

Identifiers

PMID34626671
PMCPMC8838877

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.