ArticleThe Journal of pediatrics2022
Neonatal Seizure Management: Is the Timing of Treatment Critical?
Article in The Journal of pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02431780 (A Multi-centre, Randomised, Controlled, Clinical Investigation of a Standalone Decision Support Algorithm for Neonatal Seizure Recognition), which is not on this map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multi-centre, Randomised, Controlled, Clinical Investigation of a Standalone Decision Support Algorithm for Neonatal Seizure Recognition
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Post-Asphyxial Aftercare and Management of Neonates in Low- and Middle-Income Countries: A Systematic Evidence Synthesis.Neonatology · 2025Pooled it
- Updated recommendations for the design of therapeutic trials for neonatal seizures.Pediatric research · 2026Review
- Neonatal Epilepsy: Beyond Seizures in a Developing Brain-A Narrative Review.Brain sciences · 2026Review
- Anti-Seizure Medication Use Before Electroencephalography in Infants.JAMA network open · 2025Article
- Rethinking the definition of neonatal status epilepticus.European journal of pediatrics · 2025Review
- Neonatal seizures: Advances in diagnosis and management.Epilepsia open · 2025Article
- Long-Term Neonatal EEG Modeling with DSP and ML for Grading Hypoxic-Ischemic Encephalopathy Injury.Sensors (Basel, Switzerland) · 2025Article
- Observational
- Review
- Defining neonatal status epilepticus: A scoping review from the ILAE neonatal task force.Epilepsia open · 2025Article
- Retrospective characterization of seizure semiology and treatment using continuous video-EEG monitoring in neonatal encephalopathy in Uganda.Epileptic disorders : international epilepsy journal with videotape · 2025Article
- Scaling convolutional neural networks achieves expert level seizure detection in neonatal EEG.NPJ digital medicine · 2025Article
- Timing of interventions to control neuronal chloride elevation in a model of neonatal seizures after hippocampal injury.Epilepsia · 2024Article
- Treating Seizures and Improving Newborn Outcomes for Infants with Hypoxic-Ischemic Encephalopathy.Clinics in perinatology · 2024Review
- Electrographic monitoring for seizure detection in the neonatal unit: current status and future direction.Pediatric research · 2024Review
- Falls in oxygen saturations accompany electrographic seizures in term neonates: an observational study.Pediatric research · 2024Observational
- Relationship of Neonatal Seizure Burden Before Treatment and Response to Initial Antiseizure Medication.The Journal of pediatrics · 2024Article
- Deep Learning for Generalized EEG Seizure Detection after Hypoxia-Ischemia-Preclinical Validation.Bioengineering (Basel, Switzerland) · 2024Article
- Neonatal Seizures in Low- and Middle-Income Countries: A Review of the Literature and Recommendations for the Management.Turkish archives of pediatrics · 2024Article
- Case report: Acute severe hyponatremia-induced seizures in a newborn: a community-acquired case and literature review.Frontiers in pharmacology · 2024Article
Corrections and comments
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Authors and funding
16 authors at 9 institutions in 4 countries.
Funding
Abstract
objectiveTo assess the impact of the time to treatment of the first electrographic seizure on subsequent seizure burden and describe overall seizure management in a large neonatal cohort. STUDY
designNewborns (36-44 weeks of gestation) requiring electroencephalographic (EEG) monitoring recruited to 2 multicenter European studies were included. Infants who received antiseizure medication exclusively after electrographic seizure onset were grouped based on the time to treatment of the first seizure: antiseizure medication within 1 hour, between 1 and 2 hours, and after 2 hours. Outcomes measured were seizure burden, maximum seizure burden, status epilepticus, number of seizures, and antiseizure medication dose over the first 24 hours after seizure onset.
resultsOut of 472 newborns recruited, 154 (32.6%) had confirmed electrographic seizures. Sixty-nine infants received antiseizure medication exclusively after the onset of electrographic seizure, including 21 infants within 1 hour of seizure onset, 15 between 1 and 2 hours after seizure onset, and 33 at >2 hours after seizure onset. Significantly lower seizure burden and fewer seizures were noted in the infants treated with antiseizure medication within 1 hour of seizure onset (P = .029 and .035, respectively). Overall, 258 of 472 infants (54.7%) received antiseizure medication during the study period, of whom 40 without electrographic seizures received treatment exclusively during EEG monitoring and 11 with electrographic seizures received no treatment.
conclusionsTreatment of neonatal seizures may be time-critical, but more research is needed to confirm this. Improvements in neonatal seizure diagnosis and treatment are also needed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.