Evidence map›Paper›PMID 34626614›Full record

ArticleThe Journal of investigative dermatology2022

IL-6R/Signal Transducer and Activator of Transcription 3 Signaling in Keratinocytes rather than in T Cells Induces Psoriasis-Like Dermatitis in Mice.

Advaitaa Ravipati, Sabrina Nolan, Martin Alphonse, Dustin Dikeman, Christine Youn, Yu Wang, Nicholas Orlando, Garrett Patrick, Steven Lee, Roger V Ortines and 7 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Review
  3. Role of the STAT3 Signaling Pathway in Cell Proliferation and Inflammation in Psoriasis and Approaches for Targeted Therapies: A Review.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Review
  4. Review
  5. Article
  6. IL-1β-induced STAT3 activation drives IL-17-producing CD8Journal of translational medicine · 2025
    Article
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  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Advaitaa RavipatiDepartment of Dermatology, Johns Hopkins Medicine, The Johns Hopkins University, Baltimore, Maryland, USA.
Sabrina NolanDepartment of Dermatology, Johns Hopkins Medicine, The Johns Hopkins University, Baltimore, Maryland, USA.
Martin AlphonseDepartment of Dermatology, Johns Hopkins Medicine, The Johns Hopkins University, Baltimore, Maryland, USA.
Dustin DikemanDepartment of Dermatology, Johns Hopkins Medicine, The Johns Hopkins University, Baltimore, Maryland, USA.
Christine YounDepartment of Dermatology, Johns Hopkins Medicine, The Johns Hopkins University, Baltimore, Maryland, USA.
Yu WangDepartment of Dermatology, Johns Hopkins Medicine, The Johns Hopkins University, Baltimore, Maryland, USA.
Nicholas OrlandoDepartment of Dermatology, Johns Hopkins Medicine, The Johns Hopkins University, Baltimore, Maryland, USA.
Garrett PatrickDepartment of Dermatology, Johns Hopkins Medicine, The Johns Hopkins University, Baltimore, Maryland, USA.
Steven LeeDepartment of Dermatology, Johns Hopkins Medicine, The Johns Hopkins University, Baltimore, Maryland, USA.
Roger V OrtinesDepartment of Dermatology, Johns Hopkins Medicine, The Johns Hopkins University, Baltimore, Maryland, USA.
Haiyun LiuDepartment of Dermatology, Johns Hopkins Medicine, The Johns Hopkins University, Baltimore, Maryland, USA.
Robert J MillerDepartment of Dermatology, Johns Hopkins Medicine, The Johns Hopkins University, Baltimore, Maryland, USA.
Carly A DillenDepartment of Dermatology, Johns Hopkins Medicine, The Johns Hopkins University, Baltimore, Maryland, USA.
Mark MarchittoDepartment of Dermatology, Johns Hopkins Medicine, The Johns Hopkins University, Baltimore, Maryland, USA.
S Sarah CaiDepartment of Dermatology, Johns Hopkins Medicine, The Johns Hopkins University, Baltimore, Maryland, USA.
Lloyd S MillerDepartment of Dermatology, Johns Hopkins Medicine, The Johns Hopkins University, Baltimore, Maryland, USA; Immunology, Janssen Research and Development, Spring House, Pennsylvania, USA.
Nathan K ArcherDepartment of Dermatology, Johns Hopkins Medicine, The Johns Hopkins University, Baltimore, Maryland, USA. Electronic address: narcher2@jhmi.edu.
Johns Hopkins University · US

Funding

Medical Scientist Training ProgramT32GM136577 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ANDREA L COX · 2020 to 2026
$13.4M
IL-36 responses in Staphylococcus aureus driven skin inflammationR01AR073665 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI ARCHER, NATHAN K. · 2018 to 2022
$1.8M
STAT3-mediated immunity to Staphylococcus aureus in skinR01AR069502 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI ARCHER, NATHAN K. · 2016 to 2020
$1.8M
Future Academic Scientists in DermatologyT32AR074920 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI Luis Andres Garza · 2020 to 2026
$1.4M
The role of IL-1alpha in atopic dermatitis skin inflammationK01AR073924 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI ARCHER, NATHAN K. · 2018 to 2019
$174k
NIAMS NIH HHS K01 AR073924NIAMS NIH HHS R01 AR069502NIAMS NIH HHS R01 AR073665NIAMS NIH HHS T32 AR074920NIGMS NIH HHS T32 GM136577
6 · The paper itself

Abstract

Signal transducer and activator of transcription 3 (STAT3) is important for psoriasis pathogenesis because STAT3 signaling downstream of IL-6, IL-21, IL-22, and IL-23 contributes to T helper type 17 cell development and because transgenic mice with keratinocyte (KC) STAT3 expression (K14-Stat3C mice) develop psoriasis-like dermatitis. In this study, the relative contribution of STAT3 signaling in KCs versus in T cells was evaluated in the imiquimod model of psoriasis-like dermatitis. Mice with STAT3-inducible deletion in KCs (K5-Stat3

Indexed as

DermatitisPsoriasisAnimalsChemokine CXCL10Disease Models, AnimalInterleukin-6KeratinocytesMiceMice, TransgenicReceptors, Interleukin-6STAT3 Transcription FactorT-LymphocytesChemokine CXCL10Cxcl10 protein, mouseIl6ra protein, mouseInterleukin-6Receptors, Interleukin-6Stat3 protein, mouseSTAT3 Transcription Factor

Identifiers

PMID34626614
PMCPMC8957489
OpenAlexW3204206924

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.