Evidence map›Paper›PMID 34626453›Full record

ArticleBiochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology2022

Teaching meiosis with the DNA triangle framework: A classroom activity that changes how students think about chromosomes.

Leslie Kate Wright, Paulina Cortez, Margaret A Franzen, Dina L Newman

Open access · hybridAbstract read
In one paragraph

Article in Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Biochemistry Learning in Higher Education: A Systematic Review on Methodologies and Teaching Resources.Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology
    Pooled it
  2. Article
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  8. Teaching meiosis with the DNA triangle framework: A classroom activity that changes how students think about chromosomes.Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Leslie Kate WrightThomas H. Gosnell School of Life Sciences, Rochester Institute of Technology, Rochester, New York, USA.ORCID 0000-0001-7379-0224
Paulina CortezThomas H. Gosnell School of Life Sciences, Rochester Institute of Technology, Rochester, New York, USA.
Margaret A FranzenCenter for BioMolecular Modeling, Milwaukee School of Engineering, Milwaukee, Wisconsin, USA.
Dina L NewmanThomas H. Gosnell School of Life Sciences, Rochester Institute of Technology, Rochester, New York, USA.
Rochester Institute of Technology · USMilwaukee School of Engineering · US

Funding

The Science of COVID-19 VaccinesR25GM129218 · NIGMS · MILWAUKEE SCHOOL OF ENGINEERING · PI HERMAN, TIM M. · 2018 to 2021
$1.1M
NIGMS NIH HHS R25 GM129218
6 · The paper itself

Abstract

Many biology students struggle to learn about the process of meiosis and have particular difficulty understanding the molecular basis of crossing over and the importance of homologous pairing for proper segregation. To help students overcome these challenges, we designed an activity that uses a newly developed Chromosome Connections Kit® from 3-D Molecular Designs to allow learners to explore meiosis at the molecular level. We took a backwards design approach in constructing an effective classroom activity. We developed evidence-based learning objectives and designed a crossing over activity that targets students' misconceptions and key concepts about meiosis. Assessment questions were designed based on the learning objectives and common student misconceptions. The activity consists of three parts: an interactive introductory video, a model-based activity, and reflection questions. The activity was first beta-tested with a small number of students and revised based on feedback. The revised activity was deployed in a mid-level Cell and Molecular Biology course. Analysis of pre-/post-assessment data from students who completed the activity (n = 83) showed strong learning gains on concepts related to ploidy, homology, segregation, and the mechanism and purpose of crossing over. Additionally, students who participated in the activity outperformed nonparticipants on a Genetics assessment about meiosis the following semester.

Indexed as

MeiosisStudentsChromosomesDNAHumansLearningTeachingDNAactive learningassessment of educational activitiesmolecular biologystudent conceptual and reasoning difficulties

Identifiers

PMID34626453
PMCPMC8792219
OpenAlexW3204158392

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.