Evidence map›Paper›PMID 34626381›Full record

ReviewMethods in molecular biology (Clifton, N.J.)2022

Aggrecan: Approaches to Study Biophysical and Biomechanical Properties.

Hadi Tavakoli Nia, Christine Ortiz, Alan Grodzinsky

Abstract readReview
PubMed Publisher
In one paragraph

Review in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hadi Tavakoli NiaDepartment of Biomedical Engineering, Boston University, Boston, MA, USA.
Christine OrtizDepartment of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Alan GrodzinskyDepartment of Biological Engineering, Electrical Engineering and Computer Science, and Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, UK. alg@mit.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aggrecan, the most abundant extracellular proteoglycan in cartilage (~35% by dry weight), plays a key role in the biophysical and biomechanical properties of cartilage. Here, we review several approaches based on atomic force microscopy (AFM) to probe the physical, mechanical, and structural properties of aggrecan at the molecular level. These approaches probe the response of aggrecan over a wide time (frequency) scale, ranging from equilibrium to impact dynamic loading. Experimental and theoretical methods are described for the investigation of electrostatic and fluid-solid interactions that are key mechanisms underlying the biomechanical and physicochemical functions of aggrecan. Using AFM-based imaging and nanoindentation, ultrastructural features of aggrecan are related to its mechanical properties, based on aggrecans harvested from human vs bovine, immature vs mature, and healthy vs osteoarthritic cartilage.

Indexed as

Biomechanical PhenomenaBiophysical PhenomenaAggrecansAnimalsCartilageCartilage, ArticularExtracellular Matrix ProteinsHumansMicroscopy, Atomic ForceProteoglycansAggrecansExtracellular Matrix ProteinsProteoglycansAggrecanAtomic force microscopyBiophysicsCartilageDynamic modulusElasticityExtracellular matrixNanomechanicsPoroelasticityUltrastructureViscoelasticity

Identifiers

PMID34626381

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.