Evidence map›Paper›PMID 34626311›Full record

ReviewMolecular biology reports2021

Impact of native and external factors on exosome release: understanding reactive exosome secretion and its biogenesis.

Harini Hariharan, Yasodha Kesavan, Natesan Sella Raja

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

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  13. Exosomal RNAs: Novel Potential Biomarkers for Diseases-A Review.International journal of molecular sciences · 2022
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Harini HariharanMPI Lab, Department of Genetic Engineering, SRM Institute of Science and Technology, Chengalpattu, India.
Yasodha KesavanMPI Lab, Department of Genetic Engineering, SRM Institute of Science and Technology, Chengalpattu, India.
Natesan Sella RajaMPI Lab, Department of Genetic Engineering, SRM Institute of Science and Technology, Chengalpattu, India. raja.clri@gmail.com.ORCID http://orcid.org/0000-0002-5495-7110
SRM Institute of Science and Technology · IN

Funding

Science and Engineering Research Board EEQ/2017/000707SRMIST SRMIST Excellence in research grant
6 · The paper itself

Abstract

Exosomes are minuscule vesicles secreted in the endolytic region of most mammalian cells. The release of exosomes from the cell engenders cell-to-cell signaling between cellular-compartments. The trading of exosomes between tumor and yonder cells plays a hypercritical role in tumor growth and progression. The exosome released from each tumor cell sequestrates a unique biogenetic pathway reflecting its cellular origin depending on the tumor type. However, treatment of tumor cells with certain physiological factors like drugs, chemotherapy, radiation, etc., enhance the release of exosomes and alters its biogenetic pathway compared with untreated tumor cells. In this review, we will discuss how the non-native physiological factors influence the release of exosomes and how these reactive exosomes orchestrate a unique patterning of a cargo sorting mechanism. We will also discuss the role of reactively secreted exosomes in mediating tumor metastasis, angiogenesis, and tumor progression.

Indexed as

AnimalsExosomesHumansNeoplasm MetastasisNeoplasmsNeovascularization, PathologicAngiogenesisBiogenetic pathwayExosomesMetastasisPhysiological factors

Identifiers

PMID34626311
OpenAlexW3202823905

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.