Evidence map›Paper›PMID 34626249›Full record

ArticleJournal of bone and mineral metabolism2022

Association between alcohol and bone mineral density in a Mendelian randomization study: the Dong-gu study.

Chang Kyun Choi, Sun-Seog Kweon, Young-Hoon Lee, Hae-Sung Nam, Kyeong-Soo Park, So-Yeon Ryu, Seong-Woo Choi, Min-Ho Shin

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Article in Journal of bone and mineral metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chang Kyun ChoiDepartment of Preventive Medicine, Chonnam National University Medical School, 264, Seoyang-ro, Hwasun, 58128, Republic of Korea.ORCID http://orcid.org/0000-0002-8257-3114
Sun-Seog KweonDepartment of Preventive Medicine, Chonnam National University Medical School, 264, Seoyang-ro, Hwasun, 58128, Republic of Korea.ORCID http://orcid.org/0000-0003-2378-8550
Young-Hoon LeeDepartment of Preventive Medicine & Institute of Wonkwang Medical Science, Wonkwang University College of Medicine, Iksan, Republic of Korea.ORCID http://orcid.org/0000-0003-1367-025X
Hae-Sung NamDepartment of Preventive Medicine, Chungnam National University School of Medicine, Daejeon, Republic of Korea.ORCID http://orcid.org/0000-0003-0911-4576
Kyeong-Soo ParkCardiocerebrovascular Center, Mokpo Jung-Ang Hospital, Mokpo, Republic of Korea.ORCID http://orcid.org/0000-0001-8838-4894
So-Yeon RyuDepartment of Preventive Medicine, Chosun University Medical School, Gwangju, Republic of Korea.ORCID http://orcid.org/0000-0001-5006-1192
Seong-Woo ChoiDepartment of Preventive Medicine, Chosun University Medical School, Gwangju, Republic of Korea.ORCID http://orcid.org/0000-0002-6150-3934
Min-Ho ShinDepartment of Preventive Medicine, Chonnam National University Medical School, 264, Seoyang-ro, Hwasun, 58128, Republic of Korea. mhshinx@paran.com.ORCID http://orcid.org/0000-0002-2217-5624

Funding

Chonnam National University Hospital Biomedical Research Institute CRI18094-3
6 · The paper itself

Abstract

introductionMany previous studies have reported a positive relationship between alcohol and bone mineral density (BMD). However, the causality between alcohol and BMD has not been fully evaluated. MATERIALS AND

methodsThis study enrolled 8892 participants from the Dong-gu study. Mendelian randomization (MR) using two-stage least-squared regression was used to evaluate the association between the genetically predicted amount of alcohol consumption per day and BMD. The aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism was used as instrumental variables for alcohol consumption. Age, smoking history, and BMI were adjusted in the multivariate model.

resultsSelf-reported alcohol consumption was positively related to total hip and lumbar spine BMD in both sexes. In multivariate Mendelian randomization analysis, the genetically predicted amount of alcohol consumption was positively associated with both total hip and lumbar spine BMD in men. Total hip BMD and lumbar spine BMD increased by 0.004 g/cm

conclusionIn our MR study, genetically predicted alcohol consumption was positively associated with BMD in men. This result suggests that the association between alcohol consumption and BMD is causal.

Indexed as

Bone DensityMendelian Randomization AnalysisAldehyde Dehydrogenase, MitochondrialCausalityFemaleHumansLumbar VertebraeMalePolymorphism, Single NucleotideAldehyde Dehydrogenase, MitochondrialALDH2 protein, humanAlcohol drinkingALDH2Bone densityMendelian randomization analysis

Identifiers

PMID34626249

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.