Evidence map›Paper›PMID 34626234›Full record

ArticleParasitology research2021

Involvement of the fatty acid-binding protein in the growth of Schistosoma japonicum schistosomula.

Chun-Lian Tang, Cai-Zhen Zhao, Hao Jie, Si-Ming Zhang, Rong-Hui Zhang, Yu Lu, Qun Pan

Abstract read
PubMed Publisher
In one paragraph

Article in Parasitology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Transmission-Blocking Vaccines against Schistosomiasis Japonica.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Chun-Lian Tang *Wuchang Hospital affiliated to Wuhan University of Science and Technology, No. 116 Yangyuan Street, Wuhan, 430063, China.
Cai-Zhen Zhao *Taikang Tongji (Wuhan), Hospital, No. 322 Sixin North Road, Wuhan, 430050, China.
Hao JieWuhan University of Science and Technology, No. 947 Heping Street, Wuhan, 430081, China.
Si-Ming ZhangWuhan University of Science and Technology, No. 947 Heping Street, Wuhan, 430081, China.
Rong-Hui ZhangWuchang Hospital affiliated to Wuhan University of Science and Technology, No. 116 Yangyuan Street, Wuhan, 430063, China.
Yu LuWuchang Hospital affiliated to Wuhan University of Science and Technology, No. 116 Yangyuan Street, Wuhan, 430063, China.
Qun PanWuchang Hospital affiliated to Wuhan University of Science and Technology, No. 116 Yangyuan Street, Wuhan, 430063, China. panqun_123@163.com.ORCID http://orcid.org/0000-0001-8141-259X
Wuchang University of Technology · CNWuhan University of Science and Technology · CNTongji Hospital · CN

Funding

a Natural Science Foundation of China 82070810
6 · The paper itself

Abstract

This study aimed to explore the effect and mechanism underlying the role of the Schistosoma japonicum antigen of fatty acid-binding protein (SjFABP) on the growth of the schistosomula. SjFABP levels were evaluated by quantitative real-time polymerase chain reaction of samples of mice infected with S. japonicum; SjFABP was expressed and its levels gradually increased during all stages of S. japonicum schistosomula, including on 3, 10, 14, and 21 days of the growth process. Immunohistochemistry results demonstrated that SjFABP was distributed in the parenchyma, especially in the digestive tract of the S. japonicum schistosomula. RNA interference resulted in more than 60% knockdown of SjFABP leading to a reduction in length, volume, width, and area of the schistosomula as compared to control samples, as determined by light microscopy. Terminal deoxynucleotidyl transferase dUTP nick-end labeling detection further suggested that SjFABP knockdown resulted in increased apoptosis of schistosomes. Taken together, these results suggest that SjFABP may be related to the growth and survival of S. japonicum schistosomula, thereby representing a potential target for the treatment of schistosomiasis.

Indexed as

Schistosoma japonicumSchistosomiasisSchistosomiasis japonicaAnimalsAntibodies, HelminthFatty Acid-Binding ProteinsIn Situ Nick-End LabelingMiceAntibodies, HelminthFatty Acid-Binding ProteinsFatty acid-binding proteinRNA interferenceSchistosoma japonicumSchistosomula growth

Identifiers

PMID34626234
OpenAlexW3204171585

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.