ArticleMolecular biology and evolution2022
Detecting Selection in Multiple Populations by Modeling Ancestral Admixture Components.
Article in Molecular biology and evolution, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Genomic insights into natural selection in recent human history.Nature reviews. Genetics · 2026Review
- Genomic diversification between aposematic and cryptic phenotypes of Oophaga granulifera (Anura: Dendrobatidae).Scientific reports · 2026Article
- Whole Genome Sequencing of the Moruga Hill Rice (Biotech (Basel (Switzerland)) · 2026Article
- Multiple modes of selection underlie repeated and human-mediated adaptation in a formerly migratory fish.Molecular biology and evolution · 2026Article
- Using drift coefficients as a basis for inferring times, effective population sizes, and genetic adaptations.Molecular biology and evolution · 2026Article
- Article
- Insights into human adaptation from ancient DNA.Nature genetics · 2026Review
- Global patterns of natural selection inferred using ancient DNA.bioRxiv : the preprint server for biology · 2026Article
- Integrative Genotyping and Analysis of Canine Structural Variation Using Long-read and Short-read Data.Genome biology and evolution · 2025Article
- Opinion: Why Sex-Based Genomic Differentiation Should Not Be Overlooked in Population Genetics.Molecular ecology · 2025Article
- Population Genetic Structure, Historical Effective Population Size, and Dairy Trait Selection Signatures in Chinese Red Steppe and Holstein Cattle.Animals : an open access journal from MDPI · 2025Article
- Article
- The Precision and Power of Population Branch Statistics in Identifying the Genomic Signatures of Local Adaptation.Genome biology and evolution · 2025Article
- Analysis of Evolutionary Conservation, Expression Level, and Genetic Association at a Genome-wide Scale Reveals Heterogeneity Across Polygenic Phenotypes.Molecular biology and evolution · 2024Article
- Genetic characterization of a captive marmoset (Callithrix jacchus) colony using genotype-by-sequencing.American journal of primatology · 2024Article
- From sub-Saharan Africa to China: Evolutionary history and adaptation ofScience advances · 2024Article
- Genome sequencing of 2000 canids by the Dog10K consortium advances the understanding of demography, genome function and architecture.Genome biology · 2023Article
- Natural selection has driven the recurrent loss of an immunity gene that protectsProceedings of the National Academy of Sciences of the United States of America · 2023Article
- North African fox genomes show signatures of repeated introgression and adaptation to life in deserts.Nature ecology & evolution · 2023Article
- Identifying signatures of positive selection in human populations from North Africa.Scientific reports · 2023Article
Corrections and comments
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4 authors.
Funding
Abstract
One of the most powerful and commonly used approaches for detecting local adaptation in the genome is the identification of extreme allele frequency differences between populations. In this article, we present a new maximum likelihood method for finding regions under positive selection. It is based on a Gaussian approximation to allele frequency changes and it incorporates admixture between populations. The method can analyze multiple populations simultaneously and retains power to detect selection signatures specific to ancestry components that are not representative of any extant populations. Using simulated data, we compare our method to related approaches, and show that it is orders of magnitude faster than the state-of-the-art, while retaining similar or higher power for most simulation scenarios. We also apply it to human genomic data and identify loci with extreme genetic differentiation between major geographic groups. Many of the genes identified are previously known selected loci relating to hair pigmentation and morphology, skin, and eye pigmentation. We also identify new candidate regions, including various selected loci in the Native American component of admixed Mexican-Americans. These involve diverse biological functions, such as immunity, fat distribution, food intake, vision, and hair development.
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