ArticleMedical & biological engineering & computing2021
Heart rate fragmentation, a novel approach in heart rate variability analysis, is altered in rats 4 and 12 weeks after myocardial infarction.
Article in Medical & biological engineering & computing, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Heart Rate Fragmentation: A Novel Analytic Approach to Detect Allostatic Load Among Healthy Adults.Applied psychophysiology and biofeedback · 2026Article
- Heart rate fragmentation as a marker of autonomic function in healthy young individuals: insights from graded head-up tilt test and controlled breathing.Frontiers in physiology · 2026Article
- Prescreening depression using wearable electrocardiogram and photoplethysmogram data from a psycholinguistic experiment.Physiological measurement · 2025Article
- Pattern Changes in the Heart Rate Variability of Patients Undergoing Coronary Artery Bypass Grafting Surgery.Cardiology research and practice · 2022Article
- Golden Standard or Obsolete Method? Review of ECG Applications in Clinical and Experimental Context.Frontiers in physiology · 2022Review
- Improving the effectiveness of anti-aging modalities by using the constrained disorder principle-based management algorithms.Frontiers in aging · 2022Review
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6 authors at 2 institutions in 1 country.
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Abstract
An approach recently proposed to assess ultra-rapid patterns of heart rate variability, namely heart rate fragmentation (HRF), is increased in aging and coronary disease. We aimed to evaluate and to correlate HRF with cardiac functional parameters in a rat model of myocardial infarction (MI). Wistar rats were submitted to MI (n = 18) or sham operation (n = 20), and after 4 or 12 weeks, their arterial pressure was recorded. Subsequently, cardiac function was evaluated by echocardiography. From pulse interval series, HRF patterns with zero, one, two, or three inflection points were estimated, as well as the total percentage of inflection points (PIP). Cardiac function was reduced in MI rats. Ejection fraction was smaller 4 (28 ± 3 vs 68 ± 2%, p < 0.0001) and 12 weeks after MI (38 ± 3 vs 70 ± 3%, p < 0.0001). Fractional shortening was also smaller 4 (13 ± 2 vs 41 ± 2%, p < 0.0001) and 12 weeks after MI (20 ± 2 vs 41 ± 3%, p < 0.0001). PIP was increased in MI rats 4 (74 ± 2 vs 69 ± 1%, p = 0.03) and 12 weeks after surgery (70 ± 2 vs 63 ± 1%, p = 0.02). We found a significant negative correlation between cardiac functional parameters and HRF at both 4 and 12 weeks after MI. These findings reveal that MI increases HRF, reinforcing the importance of this approach to explore pathophysiological conditions. Evaluation of heart rate fragmentation (HRF) in a rat model of myocardial infarction (MI). Wistar rats were submitted to MI (n = 18) or sham operation (n = 20), and after 4 or 12 weeks, their arterial pressure was recorded. Cardiac function was evaluated by echocardiography. From pulse interval series, HRF patterns with zero (W0), one (W1), two (W3), or three (W3) inflection points were estimated, as well as the total percentage of inflection points (PIP). Cardiac function was reduced, while PIP was increased in all MI rats. Fluent patterns (W0 and W1) decreased in MI rats after 12 weeks. Altogether, the findings reveal that MI increases HRF, reinforcing the potential of this approach to explore pathophysiological conditions.
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