ArticleInternational archives of occupational and environmental health2022
The relationship among noise, total oxidative status and DNA damage.
Article in International archives of occupational and environmental health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Occupational noise annoyance and sensitivity as potential contributors to oxidative stress in metal industry workers.Scientific reports · 2025Article
- SOD mediates mitochondrial epigenetic regulation in NIHL.Frontiers in cellular neuroscience · 2025Article
- Association of occupational noise exposure with hypertension: A cross-sectional study.Journal of clinical hypertension (Greenwich, Conn.) · 2023Article
- Hypertension, a linchpin between environmental noise exposure and the development of cardiovascular disease?Journal of clinical hypertension (Greenwich, Conn.) · 2023Article
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
purposeNoise is one of the major environmental health problems and is defined as any unpleasant sound. It was shown that prolonged exposure to noise was associated with progress of diseases. There is no study evaluating the effect of noise on the oxidative parameters of Total Antioxidant Capacity (TAC), Total Oxidant Status (TOS) and DNA damage.
aimThis study aimed to evaluate the effect of noise on TOS, TAC and DNA damage.
methodsIn this study, we included 100 textile factory workers affected by noise as a noise group, and 56 healthy volunteers employed as office workers in our hospital who were not exposed to noise as the control group. Blood samples were obtained from both the groups. Oxidative Stress (OS) was measured by Oxidative stress index (OSI), TOS and TAC. The DNA damage level was measured by 8-Hydroxydeoxyguanosine (8-OHdG).
results8-OHdG (21.8 ± 12.0 vs. 14.7 ± 5.6 pg/ml, p = 0.001),TOS (14.1 ± 2.5 vs. 10.9 ± 1.5 mol H2O2 equivalent/l, p < 0.001), TAC (0.96 ± 0.19 vs. 1.54 ± 0.28 Trolox equivalent/l, p < 0.001) and OSI (1.52 ± 0.37, etc. 0.76 ± 0.35 arbitrary units, p < 0.001) were significantly higher in noise group compared to control group. Linear regression analysis showed that noise was the independent predictor of DNA damage (β = 0.310, p < 0.001).
conclusionIn this study, we showed that TOS and DNA damage were significantly higher in subjects exposed to noise when compared with subjects of the control group. Noise was the only independent predictor of the DNA damage. Therefore, early detection of DNA damage and increased OS, early corrective measures may delay the development and progression of diseases such as hypertension, arrhythmias.
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